| Apoptosis of T-leukemia and B-myeloma cancer cells induced by hyperbaric oxygen increased phosphorylation of p38 MAPK. | |
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MedLine Citation:
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PMID: 17064767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tumor cells with different origins have different threshold to apoptosis. Hematopoietic (Jurkat, NCI-H929) cells and non-hematopoietic (A549, MCF-7) cells were received hyperbaric oxygen (HBO(2)) treatment from 2.5 to 3.5 atmosphere absolute (ATA) of 100% oxygen for 6h, and a significant percentage of apoptosis were shown only in hematopoietic Jurkat and NCI-H929 cells by either Annexin V or TUNEL assay. Oxidative stress was illustrated higher in HBO(2)-treated hematopoietic cells by superoxide fluorochrome detectors. HBO(2) treatment leads to caspase-3, caspase-7 activation and further cleavage of PARP within cells. Furthermore, the increased phosphorylation of p38 MAPK was demonstrated in both Jurkat and NCI-H929 cells. |
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Authors:
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Yen-Chen Chen; Shao-Yuan Chen; Pey-Shen Ho; Chia-Huei Lin; Ya-Yuan Cheng; Jehng-Kang Wang; Huey-Kang Sytwu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-10-24 |
Journal Detail:
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Title: Leukemia research Volume: 31 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-08 Completed Date: 2007-08-06 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 805-15 Citation Subset: IM |
Affiliation:
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Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Annexin A5
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metabolism Apoptosis* B-Lymphocytes / enzymology, pathology Caspase 3 / metabolism Caspase 7 / metabolism Collagen Type XI / metabolism Humans Hyperbaric Oxygenation* Jurkat Cells Leukemia, T-Cell / enzymology*, pathology, therapy Multiple Myeloma / enzymology*, pathology, therapy Oxygen / metabolism Phosphorylation Protein Processing, Post-Translational* p38 Mitogen-Activated Protein Kinases / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Annexin A5; 0/COL11A2 protein, human; 0/Collagen Type XI; 7782-44-7/Oxygen; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases; EC 3.4.22.-/CASP7 protein, human; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 7 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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