| Apoptosis and Bcl-2 expression in relation to age, tumor characteristics and prognosis in breast cancer. South-East Sweden Breast Cancer Group. | |
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MedLine Citation:
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PMID: 10399627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The extent of apoptosis and the expression of Bcl-2 was investigated in tumor samples from 165 women who underwent surgery for primary breast carcinoma between 1989 and 1990 in South-East Sweden. Apoptosis was assessed by a DNA fragmentation assay for flow cytometry. Bcl-2 protein expression was analyzed with immunocytochemistry. Bcl-2 immunoreactivity correlated with estrogen receptor (ER) and progesterone receptor (PgR) positivity and was inversely correlated with p53 accumulation. Apoptosis increased with patient age and a high degree of apoptosis was negatively associated with Bcl-2 immunostaining. Apoptosis showed no significant correlation with any of the other variables studied, including prognosis. The group with Bcl-2-positive tumors tended to have a lower risk of distant recurrence than others, but the association of Bcl-2 with recurrence was different in groups divided by ER and PgR status. Whereas Bcl-2 positivity indicated a low recurrence rate among PgR-negative patients, in the PgR-positive group, those with Bcl-2-positive tumors showed a non significantly higher recurrence rate than Bcl-2-negative cases. In the PgR-positive group, Bcl-2-positive tumors also appeared more frequently to be lymph node positive and DNA aneuploid. The results suggest that hormone receptor status is of importance for the prognostic role of Bcl-2. Likewise, patient age merits consideration when apoptosis is studied in human cancer. |
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Authors:
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P Holmqvist; M Lundström; O Stål |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The International journal of biological markers Volume: 14 ISSN: 0393-6155 ISO Abbreviation: Int. J. Biol. Markers Publication Date: 1999 Apr-Jun |
Date Detail:
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Created Date: 1999-08-31 Completed Date: 1999-08-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8712411 Medline TA: Int J Biol Markers Country: ITALY |
Other Details:
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Languages: eng Pagination: 84-91 Citation Subset: IM |
Affiliation:
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Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Apoptosis* Breast Neoplasms / metabolism*, physiopathology DNA Fragmentation Female Flow Cytometry Humans Middle Aged Prognosis Proto-Oncogene Proteins c-bcl-2 / biosynthesis* Receptors, Estrogen / analysis Receptors, Progesterone / analysis Tumor Suppressor Protein p53 / analysis |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-bcl-2; 0/Receptors, Estrogen; 0/Receptors, Progesterone; 0/Tumor Suppressor Protein p53 |
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