Document Detail

Apoptosis and Bcl-2 expression in relation to age, tumor characteristics and prognosis in breast cancer. South-East Sweden Breast Cancer Group.
MedLine Citation:
PMID:  10399627     Owner:  NLM     Status:  MEDLINE    
The extent of apoptosis and the expression of Bcl-2 was investigated in tumor samples from 165 women who underwent surgery for primary breast carcinoma between 1989 and 1990 in South-East Sweden. Apoptosis was assessed by a DNA fragmentation assay for flow cytometry. Bcl-2 protein expression was analyzed with immunocytochemistry. Bcl-2 immunoreactivity correlated with estrogen receptor (ER) and progesterone receptor (PgR) positivity and was inversely correlated with p53 accumulation. Apoptosis increased with patient age and a high degree of apoptosis was negatively associated with Bcl-2 immunostaining. Apoptosis showed no significant correlation with any of the other variables studied, including prognosis. The group with Bcl-2-positive tumors tended to have a lower risk of distant recurrence than others, but the association of Bcl-2 with recurrence was different in groups divided by ER and PgR status. Whereas Bcl-2 positivity indicated a low recurrence rate among PgR-negative patients, in the PgR-positive group, those with Bcl-2-positive tumors showed a non significantly higher recurrence rate than Bcl-2-negative cases. In the PgR-positive group, Bcl-2-positive tumors also appeared more frequently to be lymph node positive and DNA aneuploid. The results suggest that hormone receptor status is of importance for the prognostic role of Bcl-2. Likewise, patient age merits consideration when apoptosis is studied in human cancer.
P Holmqvist; M Lundström; O Stål
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of biological markers     Volume:  14     ISSN:  0393-6155     ISO Abbreviation:  Int. J. Biol. Markers     Publication Date:    1999 Apr-Jun
Date Detail:
Created Date:  1999-08-31     Completed Date:  1999-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8712411     Medline TA:  Int J Biol Markers     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  84-91     Citation Subset:  IM    
Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping University, Sweden.
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MeSH Terms
Age Factors
Breast Neoplasms / metabolism*,  physiopathology
DNA Fragmentation
Flow Cytometry
Middle Aged
Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
Receptors, Estrogen / analysis
Receptors, Progesterone / analysis
Tumor Suppressor Protein p53 / analysis
Reg. No./Substance:
0/Proto-Oncogene Proteins c-bcl-2; 0/Receptors, Estrogen; 0/Receptors, Progesterone; 0/Tumor Suppressor Protein p53

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