| Apoptosis and Bcl-2 Protein Expression in Human Placenta over the Course of Normal Pregnancy. | |
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MedLine Citation:
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PMID: 20608924 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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With 2 figures and 2 tables SUMMARY: Apoptosis plays a central role in organ development, homeostasis and immune defence in multicellular organisms and is strictly controlled in part by members of Bcl-2 family. The Bcl-2 is a pro-survival molecule identified through its involvement in B-cell lymphomas. The aim of the study was to evaluate the incidence of apoptosis in the human placenta at different stages of pregnancy and to correlate it further with Bcl-2 expression. A total of 96 placental samples from first trimester, mid-trimester and uncomplicated term pregnancies were collected (n = 32 + 32 + 32). M30 cyto death monoclonal antibody was used to identify apoptotic cells. The apoptosis index of first trimester placentae was 2.33 ± 1.70, mid- trimester was 1.77 ± 1.36 and term placenta was 1.15 ± 0.21. Bcl-2 protein was found immunolocalized in the cytoplasm of syncytiotrophoblast. Apoptosis index was significantly reduced in term cases as compared with first trimester (P < 0.002) and mid-trimester placentae (P = 0.01). On the contrary, Bcl-2 expression was significantly higher at term cases than in first trimester (P < 0.0001) and mid-trimester cases (P < 0.001). The present study divulges the importance of apoptosis in permitting normal physiological turnover of villous trophoblast and also exhibits the contribution of bcl-2 in maintaining syncytial integrity throughout normal pregnancy. |
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Authors:
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S Soni; G Rath; C P Prasad; S Salhan; S Saxena; A K Jain |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anatomia, histologia, embryologia Volume: 39 ISSN: 1439-0264 ISO Abbreviation: Anat Histol Embryol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2012-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704218 Medline TA: Anat Histol Embryol Country: Germany |
Other Details:
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Languages: eng Pagination: 426-31 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Verlag GmbH. |
Affiliation:
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Addresses of authors: Department of Anatomy, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India; Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi-110029, India; Institute of Pathology, ICMR, New Delhi-110029, India. |
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