| ApoptoProteomics: An integrated database for analysis of proteomics data obtained from apoptotic cells. | |
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MedLine Citation:
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PMID: 22067098 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Apoptosis is the most commonly described form of programmed cell death and dysfunction is implicated in a large number of human diseases. Many quantitative proteome analyses of apoptosis have been performed to gain insight in proteins involved in the process. This resulted in large and complex datasets which are difficult to evaluate. Therefore, we developed the ApoptoProteomics database for storage, browsing, and analysis of the outcome of large scale proteome analyses of apoptosis derived from human, mouse and rat. The proteomics data of 52 publications were integrated and unified with protein annotations from UniProt KB, the Caspase substrate database homepage (CASBAH) and gene ontology (GO). Currently, more than 2.300 records of more than 1.500 unique proteins were included, covering a large proportion of the core signalling pathways of apoptosis. Analysis of the dataset revealed a high level of agreement between the reported changes in directionality reported in proteomics studies and expected apoptosis related function and may disclose proteins without a current recognised involvement in apoptosis based on GO. Comparison between induction of apoptosis by the intrinsic and the extrinsic apoptotic signalling pathway revealed slight differences. Furthermore, proteomics has significantly contributed to the field of apoptosis in identifying hundreds of caspase substrates. The database is available at http://apoptoproteomics.uio.no. |
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Authors:
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Magnus O Arntzen; Bernd Thiede |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-8 |
Journal Detail:
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Title: Molecular & cellular proteomics : MCP Volume: - ISSN: 1535-9484 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125647 Medline TA: Mol Cell Proteomics Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Oslo, Norway. |
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