Document Detail

Apopitotic effects of dopamine and dobutamine on neutrophils of premature neonates.
MedLine Citation:
PMID:  21231849     Owner:  NLM     Status:  Publisher    
Objective. The apopitotic effects of dopamine and dobutamine used for the treatment of hypotensive premature newborns on neonatal neutrophils were investigated. Methods. Fifteen premature neonates, gestational age less than 34 weeks and birth weight less than 2500 g, were enrolled into the study. Neutrophils were isolated from the blood samples obtained for routine completed blood count, in the first 72nd hour of life. Neutrophil samples were divided into three tubes as dopamine, dobutamine, and control groups. Dopamine and dobutamine were added at 10(-4) M concentration into two separate tubes as the study groups (dopamine and dobutamine groups) and 0.9 % NaCl was added to the third tube as the control group. Apoptotic neutrophil percentages were measured in the three groups initially (hour 0) and at the first, second, fourth, and sixth hours by flow cytometric analysis. Results. The mean percentages of neutrophil apoptosis that measured at the beginning was similar in three groups. It was significantly higher in dopamine and dobutamine groups than the control group at the first, second, fourth, and sixth hours (p < 0.0005). It was also significantly higher in dopamine group, than dobutamine group at the first, second, fourth, and sixth hours (p < 0.0005). Conclusions. Dopamine and dobutamine may have an apoptotic effect on the neutrophils of premature. As neutrophils are numerically and functionally immature in premature infants, have a high risk for infection, these drugs should be used carefully and dobutamine may be preferred if there is no reason for special preference.
Yakup Aslan; Leyla Koca; Mehmet Mutlu; Yavuz Tekelioglu; Erol Erduran
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-13
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Neonatology.
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