Document Detail


Apomorphine-induced emesis in the dog--routes of administration, efficacy and synergism by naloxone.
MedLine Citation:
PMID:  2384906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apomorphine proved to be more effective as an emetic in dogs after s.c. administration than after i.m. injection with doses of 0.04 and 0.1 mg/kg. This effect is explained by an anti-emetic effect mediated by mu-receptors in the vomiting centre in the brain, which, in contrast to the chemoreceptor trigger zone, is within the blood-brain barrier. A certain delay between the stimulation of D2-receptors in the chemoreceptor trigger zone (causing emesis) and mu-receptors in the vomiting centre (producing anti-emesis) therefore results, leading to a self-limiting emesis. Blockade of the mu-receptors by naloxone increased and prolonged the effect of apomorphine. A relatively narrow range of apomorphine concentrations on s.c. administration is then effective to stimulate the chemoreceptor trigger zone, but can hardly inhibit the vomiting centre, and must therefore be considered the most suitable route for administration of apomorphine.
Authors:
R Scherkl; A Hashem; H H Frey
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  13     ISSN:  0140-7783     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-14     Completed Date:  1990-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  154-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, School of Veterinary Medicine, Free University of Berlin, FRG.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apomorphine / administration & dosage*,  pharmacokinetics,  pharmacology
Dog Diseases / chemically induced*
Dogs
Drug Synergism
Female
Injections, Intramuscular / veterinary
Injections, Intravenous / veterinary
Injections, Subcutaneous / veterinary
Male
Naloxone / pharmacology*
Vomiting / chemically induced,  veterinary*
Chemical
Reg. No./Substance:
465-65-6/Naloxone; 58-00-4/Apomorphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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