| Apomorphine-haloperidol interactions: different types of antagonism in cortical and subcortical brain regions. | |
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MedLine Citation:
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PMID: 7470869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apomorphine, a dopamine (DA) receptor stimulant induced a dose-dependent decrease in the content of the dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the olfactory tubercle and striatum of rats, but it was ineffective in the frontal cortex. Apomorphine also antagonized the haloperidol-induced accumulation of DOPAC and HAV in the olfactory tubercle and striatum, whereas in the frontal cortex it antagonized the effects of haloperidol on DOPAC but not on HVA. The total (free and conjugated) content of DA metabolites was measured in these experiments. |
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Authors:
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N G Bacopoulos; R H Roth |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 205 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-05-21 Completed Date: 1981-05-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 313-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Animals Apomorphine / pharmacology* Caudate Nucleus / drug effects Corpus Striatum / drug effects* Dopamine / metabolism Dose-Response Relationship, Drug Frontal Lobe / drug effects* Haloperidol / pharmacology* Homovanillic Acid / metabolism Male Olfactory Bulb / drug effects* Rats Receptors, Dopamine / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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MH-14092/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Dopamine; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 52-86-8/Haloperidol; 58-00-4/Apomorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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