Document Detail

Apomorphine effects on brain metabolism in neuroleptic-naive schizophrenic patients.
MedLine Citation:
PMID:  1763143     Owner:  NLM     Status:  MEDLINE    
Since neuroleptic treatment produces a significant increase in striatal metabolism relative to cortical metabolism, we wished to determine whether the dopamine agonist apomorphine (APO) might have the opposite effect, and whether it would discriminate schizophrenic patients from healthy controls. Eleven neuroleptic-naive schizophrenic patients (diagnosed according to DSM-III) and eight normal subjects were compared with respect to cerebral accumulation of 18F-fluorodeoxyglucose measured by positron emission tomography following APO, 0.75 mg/70 kg (weight adjusted), or saline. Relative striatal glucose metabolism decreased significantly after APO in schizophrenic patients but not in control subjects. Post hoc analysis of data in 12 other regions revealed that relative superior temporal metabolism decreased very slightly, but significantly, in schizophrenic patients but not in control subjects after APO, and that the posterior frontal region increased in control subjects but not in the patient group.
J M Cleghorn; H Szechtman; E S Garnett; C Nahmias; G M Brown; R D Kaplan; B Szechtman; S Franco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  40     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-02-10     Completed Date:  1992-02-10     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  135-53     Citation Subset:  IM    
Department of Psychiatry, McMaster University, Ont., Canada.
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MeSH Terms
Apomorphine / pharmacology*
Blood Glucose / metabolism*
Brain / drug effects,  physiopathology*,  radionuclide imaging*
Cerebral Cortex / drug effects,  physiopathology,  radionuclide imaging
Corpus Striatum / drug effects,  physiopathology,  radionuclide imaging
Deoxyglucose / analogs & derivatives,  metabolism
Dominance, Cerebral / drug effects,  physiology
Energy Metabolism / physiology*
Fluorodeoxyglucose F18
Neural Pathways / drug effects,  physiopathology,  radionuclide imaging
Psychiatric Status Rating Scales
Receptors, Dopamine / drug effects,  physiology*
Schizophrenia / physiopathology*,  radionuclide imaging*
Schizophrenic Psychology*
Tomography, Emission-Computed*
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Receptors, Dopamine; 154-17-6/Deoxyglucose; 58-00-4/Apomorphine; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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