Document Detail

Is apolipoprotien E codon 112 polymorphisms associated with recurrent pregnancy loss?
MedLine Citation:
PMID:  20175773     Owner:  NLM     Status:  MEDLINE    
PROBLEM: To compare the prevalence of 112T>C point mutations among women experiencing RPL with fertile control women. METHOD OF STUDY: Buccal swabs were obtained from 232 individuals: 136 with a history of >or=2 abortions, 37 with at least 2 live births and 59 with a history of deep vein thrombosis (DVT). DNA was extracted and PCR amplification of Apo E codons was performed. RESULTS: The allelic frequency of a cytosine at position 112 was 11.4% (31/272) among patients experiencing RPL, compared with a frequency of 5.4% (4/74) among the fertile controls (P = 0.19) and 19.5% (23/118) among individuals with a history of DVT. However, significantly more E3/E4 and E4/E4 genotypes were seen among individuals experiencing RPL and DVT than fertile controls (P < 0.05). CONCLUSION: Apo E4 codon 112C point mutation is, by itself, not associated with an elevated risk of recurrent pregnancy loss, but rather codon 112C in association with codon 158C is a risk factor for RPL.
Hakan Ozornek; Elif Ergin; Rajasingam S Jeyendran; Alev T Ozay; Delanie Pillai; Carolyn Coulam
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Publication Detail:
Type:  Journal Article     Date:  2010-02-17
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  64     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
EUROFERTIL Reproductive Health Center, Istanbul, Turkey.
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MeSH Terms
Abortion, Habitual / epidemiology,  genetics*
Apolipoprotein E4 / genetics
Apolipoproteins E / genetics*
Gene Frequency
Genetic Association Studies
Point Mutation
Polymerase Chain Reaction
Polymorphism, Single Nucleotide*
Protein Isoforms / genetics
Venous Thrombosis / complications,  genetics
Reg. No./Substance:
0/Apolipoprotein E4; 0/Apolipoproteins E; 0/Codon; 0/Protein Isoforms

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