Document Detail

Apolipoprotein epsilon 4 homozygosity--a determinant of restenosis after coronary angioplasty.
MedLine Citation:
PMID:  7848369     Owner:  NLM     Status:  MEDLINE    
Conventional coronary risk factors have not consistently been found to be related to restenosis after coronary angioplasty. Apolipoprotein E (apo E) gene polymorphism and/or plasma apo(a) levels were determined in 195 subjects undergoing prospective follow up and angiographic study 6 months after elective balloon angioplasty of a previously untreated coronary obstruction. Restenosis (stenosis > or = 50% plus loss of > or = 50% of initial gain) had occurred in 59 of 150 subjects for whom E genotypes were available. The apo epsilon 4 allele frequency in those with restenosis was higher than those without (0.20 vs. 0.10, P < 0.01), attributable to an excess of epsilon 4 homozygotes in the restenosis group (5 of 59 vs. 1 of 91, P < 0.04). Restenosis was not related to plasma apo(a) and the apo epsilon 4 allele was not associated with elevated levels of apo(a) as has been reported elsewhere. No relationship was found between E genotype and serum lipid and lipoprotein levels; paradoxically, LDL cholesterol was significantly lower and HDL cholesterol higher in those with restenosis. In conclusion, homozygosity for apolipoprotein epsilon 4 appears to be an important determinant of restenosis after coronary angioplasty.
F M van Bockxmeer; C D Mamotte; F R Gibbons; R R Taylor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  110     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-03     Completed Date:  1995-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  195-202     Citation Subset:  IM    
Department of Biochemistry, Royal Perth Hospital, Perth, Western Australia.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Apolipoprotein E4
Apolipoproteins E / genetics*
Coronary Disease / blood,  genetics,  therapy*
Lipoprotein(a) / blood
Middle Aged
Polymorphism, Genetic
Prospective Studies
Reg. No./Substance:
0/Apolipoprotein E4; 0/Apolipoproteins E; 0/Lipoprotein(a)

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