Document Detail


Apolipoprotein E genotype is related to progression of white matter lesion load.
MedLine Citation:
PMID:  19644067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: The relationship between white matter lesions (WMLs) and the apolipoprotein E genotype has been controversial from cross-sectional studies and no longitudinal finding has been reported. We investigated whether the apolipoprotein E genotype influences baseline and evolution over 4-year follow-up of WML volumes in a population-based sample of 1779 nondemented subjects aged 65 to 80 years old at enrollment. METHODS: The sample consisted of 3C-Dijon study participants who had 2 cerebral MRIs, at entry and at 4-year follow-up. WML volumes were estimated using a fully automatic procedure. We performed analysis of covariance to evaluate the relationship between apolipoprotein E genotype and WML load and progression. RESULTS: Multivariable analyses showed that epsilon4epsilon4 individuals had both significantly higher WML volume at baseline and higher WML increase over 4-year follow-up than noncarriers and heterozygous of the epsilon4 allele for apolipoprotein E genotype. CONCLUSION: These findings suggest it might be important to take into account WML severity when assessing the relationship between apolipoprotein E and dementia.
Authors:
Ophélia Godin; Christophe Tzourio; Pauline Maillard; Annick Alpérovitch; Bernard Mazoyer; Carole Dufouil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-30
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  40     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2009-11-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3186-90     Citation Subset:  IM    
Affiliation:
Inserm Unit 708 Neuroepidemiology, Hôpital la Salpétrière, Paris, France. ophelia.godin@upmc.fr
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Apolipoprotein E4 / genetics
Apolipoproteins E / genetics*
Brain / metabolism,  pathology*,  physiopathology
Cohort Studies
DNA Mutational Analysis
Dementia / genetics*,  pathology*,  physiopathology
Disease Progression
Female
Genetic Predisposition to Disease / genetics*
Genetic Testing
Genotype
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Nerve Fibers, Myelinated / pathology*
Polymorphism, Genetic / genetics
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Apolipoprotein E4; 0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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