Document Detail


Apolipoprotein A-I-containing lipoproteins in human umbilical cord blood. Relation to proapolipoprotein A-I and lecithin:cholesterol acyltransferase.
MedLine Citation:
PMID:  1908326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipids, apolipoproteins, lipoproteins, as well as lipoproteins containing both apo A-I and apo A-II (Lp A-I:A-II) or apo A-I but no apo A-II (Lp A-I), proapolipoprotein (proapo) A-I and the activity of lecithin:cholesterol acyltransferase (LCAT), were investigated in umbilical cord sera of 67 term human neonates (30 females and 37 males). Lp A-I and Lp A-I:A-II were present in umbilical cord sera with levels of 0.26 +/- 0.1 and 0.33 +/- 0.15 g/l, respectively. Furthermore, the absolute amount of proapo A-I was lower in cord blood than in adult plasma, but in view of the lower apo A-I levels in umbilical cord sera it comprised 10.48 +/- 3.86% of total apo A-I and was thus significantly higher than in adult plasma (7.1 +/- 0.9%). Proapo A-I was highly correlated with HDL cholesterol and apo A-I. Total serum LCAT activity was about 50% of adult plasma and was highly correlated with Lp A-I, but not with Lp A-I:A-II. We conclude that human umbilical cord serum contains both Lp A-I and Lp A-I:A-II particles and that the LCAT activity is predominantly related with the Lp A-I subfraction. The higher percentage in umbilical cord sera of proapo A-I may indicate a higher turnover of apo A-I or a lower activity of the proapo A-I cleaving enzyme which is still not identified.
Authors:
A Barkia; E Thiemann; P Czekelius; A Wiegel; A Leroy; J C Fruchart; A Steinmetz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  59     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1991  
Date Detail:
Created Date:  1991-09-24     Completed Date:  1991-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  352-7     Citation Subset:  IM    
Affiliation:
SERLIA, INSERM U325, Institut Pasteur, Lille, France.
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MeSH Terms
Descriptor/Qualifier:
Apolipoprotein A-I
Apolipoproteins A / blood*
Cholesterol, HDL / blood
Female
Fetal Blood / metabolism*
Humans
Lipoproteins / blood*
Male
Phosphatidylcholine-Sterol O-Acyltransferase / blood
Protein Precursors / blood
Chemical
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoproteins A; 0/Cholesterol, HDL; 0/Lipoproteins; 0/Protein Precursors; EC 2.3.1.43/Phosphatidylcholine-Sterol O-Acyltransferase

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