Document Detail

Apolipoprotein a-I as a carrier of lipopolysaccharide into rat hepatocytes.
MedLine Citation:
PMID:  24288754     Owner:  NLM     Status:  In-Data-Review    
Apolipoprotein A-I-mediated transport of LPS into isolated rat hepatocytes was demonstrated by means of fluorescent microscopy and spectrofluorometry. The efficiency of intracellular endotoxin transport in a complex with apolipoprotein A-I significantly exceeded the absorption of LPS without this carrier. Our results suggest that the mechanism of the anti-inflammatory effect of HDL and apolipoprotein A-I can be related to alternative pathway for metabolic degradation of this endotoxin with the involvement of lipoprotein receptors.
D V Sumenkova; L M Polyakov; L E Panin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  155     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  738-40     Citation Subset:  IM    
Research Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
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