| Apolipoprotein A-IV regulates chylomicron metabolism-mechanism and function. | |
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MedLine Citation:
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PMID: 22207575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary fat is an important mediator of atherosclerosis and obesity. Despite its importance in mediating metabolic disease, there is still much unknown about dietary fat absorption in the intestine and especially the detailed biological roles of intestinal apolipoproteins involved in that process. We were specifically interested in determining the physiological role of the intestinal apolipoprotein A-IV (A-IV) using A-IV knockout (KO) mice. A-IV is stimulated by fat absorption in the intestine and is secreted on nascent chylomicrons into intestinal lymph. We found that A-IV KO mice had reduced plasma triglyceride (TG) and cholesterol levels and that this hypolipidemia persisted on a high-fat diet. A-IV KO did not cause abnormal intestinal lipid absorption, food intake, or adiposity. Additionally, A-IV KO did not cause abnormal liver TG and cholesterol metabolism, as assessed by measuring hepatic lipid content, lipogenic and cholesterol synthetic gene expression, and in vivo VLDL secretion. Instead, A-IV KO resulted in the secretion of larger chylomicrons from the intestine into the lymph, and those chylomicrons were cleared from the plasma more slowly than wild-type chylomicrons. These data suggest that A-IV has a previously unknown role in mediating the metabolism of chylomicrons, and therefore may be important in regulating plasma lipid metabolism. |
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Authors:
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Alison B Kohan; Fei Wang; Xiaoming Li; Suzanne Bradshaw; Qing Yang; Jody L Caldwell; Tera M Bullock; Patrick Tso |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-12-29 |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 302 ISSN: 1522-1547 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-16 Completed Date: 2012-05-04 Revised Date: 2012-05-23 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
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Languages: eng Pagination: G628-36 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of Cincinnati, OH 45237, USA. alison.kohan@uc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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genetics Animals Apolipoproteins A / genetics, metabolism* Body Composition Chylomicrons / metabolism* Dietary Fats / metabolism Eating / genetics Gene Expression Regulation / physiology Intestinal Absorption / physiology Lipid Metabolism / physiology Lipids / blood Liver / metabolism Mice Mice, Inbred C57BL Mice, Knockout |
| Grant Support | |
ID/Acronym/Agency:
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DK-059630/DK/NIDDK NIH HHS; DK-076928/DK/NIDDK NIH HHS; F32-091173-01//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins A; 0/Chylomicrons; 0/Dietary Fats; 0/Lipids; 0/apolipoprotein A-IV |
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