Document Detail


Apolipoprotein E polymorphism in the early onset of coronary heart disease.
MedLine Citation:
PMID:  11780396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the relationship between apolipoprotein E (apoE) polymorphism and the early onset of coronary heart disease (CHD) and the effect of apoE on lipids and lipoproteins in healthy Chinese subjects. METHODS: Sixty-eight patients with CHD younger than 55 years (CHD1), 136 patients with CHD older than 65 years (CHD2), and 136 healthy subjects were enrolled, and their plasma levels of triglyceride (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were determined. The apoE genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: apoE 3/4 genotype and E4 allele frequency in the CHD1 group were higher than those in the CHD2 group and healthy subjects, while no differences were found between CHD2 and healthy subjects. Meanwhile, the plasma levels of TC and low density lipoprotein cholesterol (LDL-C) were higher in the CHD2 group than in both CHD1 group and healthy subjects. Each apoE isoprotein has variable TC and LDL-C levels that is E2 (E2/2 + E2/3) < E3(E3/3) < E4(E4/4 + E3/4). CONCLUSION: apoE is one of the genetic factors that affect TC and LDL-C levels, and apoE 4 has a very close relation to CHD, suggesting that apoE 4 is an independent genetic factor of the early onset of CHD.
Authors:
Z Yang; T Zhu; G Ma; H Yin; W Qian; F Zhang; K Cao; W Ma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  114     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2002-01-08     Completed Date:  2002-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  983-5     Citation Subset:  IM    
Affiliation:
Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Aged, 80 and over
Alleles
Apolipoproteins E / genetics*
Cholesterol / blood
Cholesterol, HDL / blood
Coronary Disease / genetics*,  pathology
DNA / genetics
Gene Frequency
Genotype
Humans
Middle Aged
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Risk Factors
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Cholesterol, HDL; 0/Triglycerides; 57-88-5/Cholesterol; 9007-49-2/DNA

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