| Apolipoprotein E polymorphism in childhood nephrotic syndrome. | |
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MedLine Citation:
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PMID: 12042894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent clinical reports have demonstrated that the progression and prognosis of renal diseases are possibly influenced by apolipoprotein E (apoE) genotypes and alleles. In this study we investigated whether apoE genotypes and alleles can be a prognostic criterion for the steroid responsiveness in childhood nephrotic syndrome. One hundred and seven pediatric patients with primary idiopathic nephrotic syndrome and 83 healthy volunteers were enrolled in the study. Eighty-seven of the patients had steroid-sensitive nephrotic syndrome (SSNS) and 20 had steroid-resistant nephrotic syndrome (SRNS). The varepsilon2 allele frequency and varepsilon2/3 genotype frequency of the SNRS group were statistically higher when compared with SSNS and control groups ( P<0.05). The higher frequency of the varepsilon2 allele in steroid resistant nephrotic patients suggests that the varepsilon2 allele gives a possible genetic predisposition to steroid resistance in our population, but further studies are needed to clarify this subject. |
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Authors:
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Gulen Attila; Aytul Noyan; Aysun Karabay Bayazit; Esmeray Acartürk; Ali Anarat |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 17 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-06-03 Completed Date: 2002-07-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 359-62 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Cukurova University School of Medicine, 01330 Adana, Turkey. gattila@mail.cu.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Apolipoprotein E2 Apolipoprotein E3 Apolipoproteins E / genetics* Child Child, Preschool Drug Resistance Female Gene Frequency Genotype Humans Infant Male Nephrotic Syndrome / drug therapy, genetics* Polymorphism, Genetic* Prognosis Reference Values Steroids / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein E2; 0/Apolipoprotein E3; 0/Apolipoproteins E; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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