| Apolipoprotein E polymorphism has no independent effect on plasma levels of lipoprotein(a). | |
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MedLine Citation:
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PMID: 9199278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies show conflicting results concerning an influence of apolipoprotein E (apo E) phenotype on lipoprotein(a) (Lp(a)) plasma levels. We speculated that it is not the apo E phenotype itself but rather its effect on plasma lipid concentrations that might influence Lp(a) levels. In 1562 subjects concentrations of triglycerides, LDL-cholesterol and Lp(a) were measured by standard laboratory methods. Apo(a) and apo E isoforms were determined by sodium dodecyl sulfate gel electrophoresis and isoelectric focusing, respectively, followed by immunoblotting. An univariate analysis revealed a significant influence of apo(a) isoforms, apo E phenotype, triglycerides and LDL-cholesterol on Lp(a) plasma levels (ANOVA: P < 0.001, P < 0.02, P < 0.001 and P < 0.001, respectively). In a multivariate analysis, however, the influence of the apo E phenotype was no longer significant (P>0.10), whereas apo(a) isoforms, LDL-cholesterol quintiles and triglyceride quintiles explained 29.2, 2.8 and 1.0% of the variation of the Lp(a) levels (for all three variables: P < 0.001). We conclude that apo E polymorphism does not exert an independent effect on Lp(a) concentrations. Any influence is mediated through the effect of apo E polymorphism on plasma lipids. |
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Authors:
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M M Ritter; J Gewitsch; W O Richter; H C Geiss; M W Wildner; P Schwandt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Atherosclerosis Volume: 131 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-08-11 Completed Date: 1997-08-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: IRELAND |
Other Details:
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Languages: eng Pagination: 243-8 Citation Subset: IM |
Affiliation:
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Medical Department II, Klinikum Grosshadern, University of Munich, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Aged, 80 and over Analysis of Variance Apolipoproteins E / blood, genetics* Child Child, Preschool Cholesterol, LDL / blood Female Humans Hyperlipidemias / blood, genetics Immunoblotting Lipoprotein(a) / blood* Male Middle Aged Phenotype Polymorphism, Genetic / genetics* Retrospective Studies Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Cholesterol, LDL; 0/Lipoprotein(a); 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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