| Apolipoprotein E polymorphism and coronary artery disease. | |
| | |
MedLine Citation:
|
PMID: 6882285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Lipid status and apolipoprotein E phenotypes were tested in 1000 patients who underwent coronary angiography. The same number of factory employees was chosen as a control group. We distinguished between six different apolipoprotein E phenotypes and determined their frequencies in all groups. For the three homozygous phenotypes E3/3, E4/4, and E2/2, the percentage distribution in the group of factory employees was 62.7%, 2.3%, and 0.8%, respectively; for the three heterozygous phenotypes E4/3, E3/2, and E4/2, we determined frequencies of 20.3%, 11.0%, and 3.0%, respectively. In the group of patients with and without signs of coronary atherosclerosis, we observed almost the same frequencies except that heterozygotes (E3/2) occurred significantly more frequently in the group of coronary angiography patients unaffected by coronary sclerosis. Cholesterol and triglyceride values were significantly elevated in patients with coronary artery disease, whereas high density lipoprotein cholesterol levels were not significantly different. The data further suggest that apolipoprotein E2/2 homozygosity, despite the presence of beta-very low density lipoproteins in the plasma of these patients, cannot be considered a biochemical indicator of an increased risk of coronary atherosclerosis. On the other hand, apolipoprotein E3/2 heterozygosity may have a protective effect on the development of early atherosclerosis. |
| | |
Authors:
|
H J Menzel; R G Kladetzky; G Assmann |
Related Documents
:
|
14583365 - Effect of apolipoprotein e alleles and angiotensin-converting enzyme insertion/deletion... 18178395 - Effect of statin therapy before q-wave myocardial infarction on myocardial perfusion. 9748425 - Identification of oxidized low-density lipoprotein in human serum by nmr spectroscopy. 14533615 - Ezetimibe for lowering blood cholesterol. 15665255 - Magnesium deficiency in critical illness. 2260155 - Effects of nimodipine on infarct size and cerebral acidosis after middle cerebral arter... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Arteriosclerosis (Dallas, Tex.) Volume: 3 ISSN: 0276-5047 ISO Abbreviation: Arteriosclerosis Publication Date: 1983 Jul-Aug |
Date Detail:
|
Created Date: 1983-09-20 Completed Date: 1983-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8401388 Medline TA: Arteriosclerosis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 310-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Apolipoproteins / blood, genetics* Apolipoproteins E Cholesterol / blood Cholesterol, HDL Coronary Disease / etiology* Electrophoresis, Polyacrylamide Gel Female Genotype Humans Isoelectric Focusing Lipoproteins, HDL / blood Lipoproteins, VLDL / blood, genetics* Male Middle Aged Phenotype Polymorphism, Genetic Risk |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins; 0/Apolipoproteins E; 0/Cholesterol, HDL; 0/Lipoproteins, HDL; 0/Lipoproteins, VLDL; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of blindfolding a unilateral eye on so-called central nystagmus.
Next Document: Serum triglyceride and risk of coronary heart disease, stroke, and total mortality in Japanese-Ameri...