Document Detail

Apolipoprotein E polymorphism is associated with both number of diseased vessels and extent of coronary artery disease in Czech patients with CAD.
MedLine Citation:
PMID:  22837136     Owner:  NLM     Status:  MEDLINE    
AIMS: The impact of ApoE polymorphism on angiographic parameters was assessed in patients referred for coronary angiography.
METHODS: Elective coronary angiography was performed in 671 subjects (525 men, 146 women, mean age 60 ± 10 years) with symptoms of ischemic heart disease. The patients were divided into: no CAD group (smooth coronary vessels, n=83), one-vessel (n=155), two-vessel (n=170) and three-vessel disease (n=196). Patients with stenoses 0-50% were excluded. Within patients with CAD, we evaluated overall extent of CAD measured by the number of stenotic segments according to AHA (1 segment vs. 2-3 vs. ≥4), and the severity of the most serious stenosis (in percent). ApoE genotype was determined using real-time PCR.
RESULTS: The frequency of ε2/ε3 genotype (n=56) was lower in the three-vessel disease group compared to one-vessel disease (OR=0.25, P=0.0019), two-vessel disease (OR=0.31, P=0.0114) or no CAD group (OR=0.24, P=0.0057). Frequency of ε2/ε3 decreased with the number of affected segments (1 vs. ≥4: OR=0.35, P=0.0143). The ε3/ε4+ε4/ε4 genotypes (n=123) were more frequent in CAD patients altogether compared with no CAD group (OR=2.30, P=0.019), while no impact of the ε4 allele on angiographic parameters within the CAD patients was detected. In ε2/ε3 carriers with CAD, lower LDL-cholesterol, total cholesterol and lower use of lipid-lowering drugs were observed.
CONCLUSIONS: The results show predominantly focal form of CAD in patients with ε2/ε3 genotype. Lower LDL-cholesterol and total cholesterol may play the key role, although other contributing factors are discussed.
Jan Machal; Anna Vasku; Ota Hlinomaz; Petra Linhartova; Ladislav Groch; Jiri Vitovec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia     Volume:  156     ISSN:  1213-8118     ISO Abbreviation:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-27     Completed Date:  2012-12-17     Revised Date:  2013-01-24    
Medline Journal Info:
Nlm Unique ID:  101140142     Medline TA:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  151-8     Citation Subset:  IM    
Department of Pathophysiology, Faculty of Medicine, Masaryk University Brno, Czech Republic.
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MeSH Terms
Apolipoproteins E / genetics*
Cholesterol / blood
Coronary Angiography
Coronary Artery Disease / blood,  genetics*,  radiography
Middle Aged
Polymorphism, Genetic*
Reg. No./Substance:
0/Apolipoproteins E; 57-88-5/Cholesterol

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