| Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease. | |
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MedLine Citation:
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PMID: 21907569 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The largest genetic risk for late-onset Alzheimer's disease (AD) resides at the apolipoprotein E gene (APOE) locus, which has three common alleles (ɛ2, ɛ3, ɛ4) that encode three isoforms (apoE2, apoE3, apoE4). The very strong association of the APOE ɛ4 allele with AD risk and its role in the accumulation of amyloid β in brains of people and animal models solidify the biological relevance of apoE isoforms but do not provide mechanistic insight. The innate immune response is consistently observed in AD and is a likely contributor to neuronal injury and response to injury. Here we review emerging data showing that apoE isoform regulation of multiple facets of the innate immune response in the brain may alter AD not only through amyloid β-dependent mechanisms, but also through other, amyloid β-independent mechanisms. |
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Authors:
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C Dirk Keene; Eiron Cudaback; Xianwu Li; Kathleen S Montine; Thomas J Montine |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-8 |
Journal Detail:
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Title: Current opinion in neurobiology Volume: - ISSN: 1873-6882 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111376 Medline TA: Curr Opin Neurobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pathology, University of Washington, Seattle, WA, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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