| Apolipoprotein E in Alzheimer's disease and other neurological disorders. | |
| | |
MedLine Citation:
|
PMID: 21349439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Apolipoprotein E (APOE) is a 299-aminoacid protein encoded by the APOE gene. Three common polymorphisms in the APOE gene, ɛ2, ɛ3, and ɛ4, result in a single aminoacid change in the APOE protein. APOE ɛ2, ɛ3, and ɛ4 alleles strongly alter, in a dose-dependent manner, the likelihood of developing Alzheimer's disease and cerebral amyloid angiopathy. In particular, APOE ɛ4 is associated with increased risk for Alzheimer's disease whereas APOE ɛ2 is associated with decreased risk. The effects of APOE genotype on risk of these diseases are likely to be mediated by differential effects of APOE on amyloid-β accumulation in the brain and its vasculature. Response to treatment for Alzheimer's disease might differ according to APOE genotype. Because convincing evidence ties the APOE genotype to risk of Alzheimer's disease and cerebral amyloid angiopathy, APOE has been studied in other neurological diseases. APOE ɛ4 is associated with poor outcome after traumatic brain injury and brain haemorrhage, although the mechanisms underlying these associations are unclear. The possibility that APOE has a role in these and other neurological diseases has been of great interest, but convincing associations have not yet emerged. |
| | |
Authors:
|
Philip B Verghese; Joseph M Castellano; David M Holtzman |
Related Documents
:
|
21255199 - Challenges to the development of disease-modifying therapies in parkinson's disease. 23204959 - Percutaneous fasciotomy for the treatment of dupuytren's disease-a systematic review. 21176749 - Fifty years of balkan endemic nephropathy in romania: some aspects of the endemic focus... 21494079 - Vogt-koyanagi-harada disease occurring during pegylated interferon-α2b and ribavirin c... 17319269 - Severe acute respiratory syndrome--retrospect and lessons of 2004 outbreak in china. 21331369 - The pathogenesis of alzheimer's disease: a reevaluation of the "amyloid cascade hypothe... 8572729 - Association of hand and knee osteoarthritis: evidence for a polyarticular disease subset. 4243829 - Chagas disease of the colon and rectum. 8144299 - Protective effect of bcg against tuberculous meningitis and miliary tuberculosis: a met... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Lancet neurology Volume: 10 ISSN: 1474-4465 ISO Abbreviation: Lancet Neurol Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-25 Completed Date: 2011-04-21 Revised Date: 2012-10-09 |
Medline Journal Info:
|
Nlm Unique ID: 101139309 Medline TA: Lancet Neurol Country: England |
Other Details:
|
Languages: eng Pagination: 241-52 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Neurology, Hope Center for Neurological Disorders, and the Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alzheimer Disease
/
diagnosis*,
genetics* Animals Apolipoproteins E / genetics* Humans Nervous System Diseases / diagnosis, genetics Polymorphism, Genetic / genetics |
| Grant Support | |
ID/Acronym/Agency:
|
AG026276/AG/NIA NIH HHS; AG034004/AG/NIA NIH HHS; AG03991/AG/NIA NIH HHS; AG13956/AG/NIA NIH HHS; F31 AG034004-04/AG/NIA NIH HHS; NS034467/NS/NINDS NIH HHS; R37 AG013956-16/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins E |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo.
Next Document: Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease...