Document Detail

Apolipoprotein E highly correlates with AbetaPP- and tau-related markers in human cerebrospinal fluid.
MedLine Citation:
PMID:  18997294     Owner:  NLM     Status:  MEDLINE    
We assessed cerebrospinal fluid (CSF) levels of apolipoprotein E (apoE), phospholipid transfer protein (PLTP) activity, cholesterol, secreted amyloid-beta protein precursor alpha and beta (sAbetaPPalpha, sAbetaPPbeta), amyloid-beta peptides 1-40 (Abeta_{40}) and 1-42 (Abeta_{42}), total tau and tau phosphorylated at threonine 181 (pTau) in neurologically healthy, cognitively intact adults. ApoE significantly correlated with sAbetaPPalpha (r = 0.679), sAbetaPPbeta (r = 0.634), Abeta_{40} (r = 0.609), total and pTau (r = 0.589 and r = 0.673, respectively, all p < 0.001), PLTP activity (r = 0.242, p = 0.002) and cholesterol (r = 0.194, p < 0.01). PLTP activity significantly correlated with sAbetaPPalpha (r = 0.292), sAbetaPPbeta (r = 0.281), total and pTau (r = 0.265 and 0.258, respectively; all p <or= 0.001). Using partial correlations of CSF biomarkers with apoE, PLTP activity, age and gender, apoE remained significantly correlated with sAbetaPPalpha, sAbetaPPbeta, Abeta_{40}, total and pTau (p < 0.001). The presence of apoE epsilon2 was associated with lower levels of apoE, PLTP activity and Abeta_{42}, while APOEepsilon4} had no significant impact on any of the measured variables. Our data suggest that there is a significant physiological link between apoE and AbetaPP, as well as between apoE and tau in neurologically healthy, cognitively intact individuals.
Simona Vuletic; Ge Li; Elaine R Peskind; Hal Kennedy; Santica M Marcovina; James B Leverenz; Eric C Petrie; Virginia M-Y Lee; Douglas Galasko; Gerard D Schellenberg; John J Albers
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  15     ISSN:  1387-2877     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-01-06     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  409-17     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Aging / metabolism
Amyloid beta-Protein Precursor / cerebrospinal fluid*
Apolipoproteins E / cerebrospinal fluid*
Biological Markers
Cholesterol / cerebrospinal fluid
Middle Aged
Nerve Degeneration / cerebrospinal fluid,  metabolism
Neuropsychological Tests
Phospholipid Transfer Proteins / cerebrospinal fluid
Reference Values
Regression Analysis
Young Adult
tau Proteins / cerebrospinal fluid*
Grant Support
K08 AG023670/AG/NIA NIH HHS; K08 AG023670/AG/NIA NIH HHS; K23 AG20020/AG/NIA NIH HHS; P01 HL030086/HL/NHLBI NIH HHS; P01 HL030086-240012/HL/NHLBI NIH HHS; P50 AG005136/AG/NIA NIH HHS; P50 AG005136-25/AG/NIA NIH HHS; P50 AG05136/AG/NIA NIH HHS
Reg. No./Substance:
0/Amyloid beta-Protein Precursor; 0/Apolipoproteins E; 0/Biological Markers; 0/Phospholipid Transfer Proteins; 0/tau Proteins; 97C5T2UQ7J/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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