Document Detail


Apolipoprotein E genotypes as predictors of high-risk groups for developing hyperlipidemia in kidney transplant recipients undergoing sirolimus treatment.
MedLine Citation:
PMID:  16378065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hypercholesterolemia (HCHL) and hypertriglyceridemia (HTRG) have emerged as the most significant metabolic consequences of therapy with sirolimus. Lipid status can be exacerbated by a variety of factors in the posttransplant setting, including genetic factors. Apoliprotein E (Apo E) polymorphism is an established genetic risk factor for hyperlipidemia. We studied the association between Apo E gene polymorphisms and lipids after kidney transplantation in patients undergoing sirolimus treatment. METHODS: We studied 98 kidney transplant patients (KTP) with stable renal allograft undergoing sirolimus treatment: 39 with HCHL and HTRG within 90 days postsirolimus treatment (PST) and 59 without hyperlipidemia PST. Apo E genotyping was performed using INNO-LiPA-ApoE. RESULTS: The cholesterol and the triglyceride values between the groups were 323.3+/-71.6 vs. 180.9+/-31.2 mg/dL (P<0.001) and 318.9+/-97.2 vs. 159.7+/-38.7 mg/dL (P<0.001). There was a significant difference in the genotype distribution of the hyperlipidemia and normal groups (P=0.009) with the percentages in each group as follows: E2/2 and E3/2: 12.8 vs. 5.1%; E3/3: 69.2% vs. 86.4%; and E4/3 and E4/4: 18.0% vs. 8.5%. We observed a higher number of patients with the genotype E3/3 in the group without hyperlipidemia PST (P=0.039). E3/2 and E4/4 genotype frequencies were higher in patients with hyperlipidemia PST. LDL levels in the hyperlipidemia PST group was statistical significant higher (P<0.001) and we observed an association between Apo E allelic distribution and LDL (P=0.005). CONCLUSIONS: Genetic factors, as Apo E genotypes, could allow the early identification of patients who are at a high risk for developing hyperlipidemia PST.
Authors:
Daniel G Maluf; Valeria R Mas; Kellie J Archer; Kenneth Yanek; Anne King; Andrea Ferreira-Gonzalez; Robert A Fisher; Marc Posner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplantation     Volume:  80     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-26     Completed Date:  2006-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1705-11     Citation Subset:  IM    
Affiliation:
Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298-0248, USA. dgmaluf@vcu.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Apolipoproteins E / genetics*
Cholesterol / blood
Creatinine / blood
Female
Gene Frequency
Genotype
Humans
Hyperlipidemias / chemically induced,  epidemiology*,  genetics
Immunosuppressive Agents / adverse effects
Kidney Transplantation / immunology,  physiology*
Lipoproteins, LDL / blood
Male
Middle Aged
Retrospective Studies
Risk Factors
Sirolimus / adverse effects*
Triglycerides / blood
Virginia
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Immunosuppressive Agents; 0/Lipoproteins, LDL; 0/Triglycerides; 53123-88-9/Sirolimus; 57-88-5/Cholesterol; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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