| Apolipoprotein E genotypes as predictors of high-risk groups for developing hyperlipidemia in kidney transplant recipients undergoing sirolimus treatment. | |
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MedLine Citation:
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PMID: 16378065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hypercholesterolemia (HCHL) and hypertriglyceridemia (HTRG) have emerged as the most significant metabolic consequences of therapy with sirolimus. Lipid status can be exacerbated by a variety of factors in the posttransplant setting, including genetic factors. Apoliprotein E (Apo E) polymorphism is an established genetic risk factor for hyperlipidemia. We studied the association between Apo E gene polymorphisms and lipids after kidney transplantation in patients undergoing sirolimus treatment. METHODS: We studied 98 kidney transplant patients (KTP) with stable renal allograft undergoing sirolimus treatment: 39 with HCHL and HTRG within 90 days postsirolimus treatment (PST) and 59 without hyperlipidemia PST. Apo E genotyping was performed using INNO-LiPA-ApoE. RESULTS: The cholesterol and the triglyceride values between the groups were 323.3+/-71.6 vs. 180.9+/-31.2 mg/dL (P<0.001) and 318.9+/-97.2 vs. 159.7+/-38.7 mg/dL (P<0.001). There was a significant difference in the genotype distribution of the hyperlipidemia and normal groups (P=0.009) with the percentages in each group as follows: E2/2 and E3/2: 12.8 vs. 5.1%; E3/3: 69.2% vs. 86.4%; and E4/3 and E4/4: 18.0% vs. 8.5%. We observed a higher number of patients with the genotype E3/3 in the group without hyperlipidemia PST (P=0.039). E3/2 and E4/4 genotype frequencies were higher in patients with hyperlipidemia PST. LDL levels in the hyperlipidemia PST group was statistical significant higher (P<0.001) and we observed an association between Apo E allelic distribution and LDL (P=0.005). CONCLUSIONS: Genetic factors, as Apo E genotypes, could allow the early identification of patients who are at a high risk for developing hyperlipidemia PST. |
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Authors:
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Daniel G Maluf; Valeria R Mas; Kellie J Archer; Kenneth Yanek; Anne King; Andrea Ferreira-Gonzalez; Robert A Fisher; Marc Posner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transplantation Volume: 80 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-26 Completed Date: 2006-01-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: United States |
Other Details:
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Languages: eng Pagination: 1705-11 Citation Subset: IM |
Affiliation:
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Division of Transplantation, Department of Surgery, Virginia Commonwealth University, Richmond, VA 23298-0248, USA. dgmaluf@vcu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Apolipoproteins E / genetics* Cholesterol / blood Creatinine / blood Female Gene Frequency Genotype Humans Hyperlipidemias / chemically induced, epidemiology*, genetics Immunosuppressive Agents / adverse effects Kidney Transplantation / immunology, physiology* Lipoproteins, LDL / blood Male Middle Aged Retrospective Studies Risk Factors Sirolimus / adverse effects* Triglycerides / blood Virginia |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Immunosuppressive Agents; 0/Lipoproteins, LDL; 0/Triglycerides; 53123-88-9/Sirolimus; 57-88-5/Cholesterol; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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