| Apolipoprotein E genotype and sex influence C-reactive protein levels regardless of exercise training status. | |
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MedLine Citation:
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PMID: 18702945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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C-reactive protein (CRP) is a marker for systemic inflammation and increased cardiovascular disease risk. Regular exercise may decrease CRP. Apolipoprotein E (apo E) has 3 common genotype variants--E2/3, 3/3, and 3/4--that modulate lipid metabolism and may have other metabolic physiologic roles, including some evidence that the genotype affects CRP levels. We assessed fasting serum CRP in 117 (male = 51, female = 66) healthy adults who volunteered for a 6-month aerobic exercise program. Both pre- and posttraining measurements were available in 71 (male = 31, female = 40) subjects. At baseline and follow-up, the numbers of subjects in the 3 groups were approximately equal: 2/3, n = 33 and 20; 3/3, n = 41 and 26; and 3/4, n = 43 and 25. At baseline, CRP levels differed by apo E genotype: means +/- SD were 2.84 +/- 2.18, 2.59 +/- 2.34, and 1.90 +/- 2.13 mg/L for E2/3, 3/3, and 3/4 subjects, respectively (3/4 vs 2/3, P < .05). In women, CRP was higher than that in men (3.14 +/- 2.49 vs 2.12 +/- 2.13 mg/L, P < .006). Exercise failed to affect CRP in the entire cohort (2.68 +/- 2.38 vs 2.52 +/- 2.48 mg/L) or in any apo E genotype group, and the apo E genotype effect observed at baseline persisted after training. In a largely white study cohort, CRP is higher in apo E3/3 than in 3/4 subjects and in women compared with men, but remains unchanged by 6 months of standard aerobic exercise training of the volume and higher intensity promoted by national organizations to reduce cardiovascular disease risk. How apo E genotype affects CRP is not known. |
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Authors:
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Theodore J Angelopoulos; Mary P Miles; Joshua Lowndes; Stephen A Sivo; Richard L Seip; Linda S Pescatello; Robert F Zoeller; Paul S Visich; Paul M Gordon; Niall M Moyna; Paul D Thompson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 57 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-15 Completed Date: 2008-09-16 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 1204-10 Citation Subset: IM |
Affiliation:
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Center for Lifestyle Medicine and Department of Health Professions, University of Central Florida, Orlando, FL 32826, USA. tangelop@mail.ucf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anthropometry Apolipoproteins E / genetics* C-Reactive Protein / metabolism* Cardiovascular Physiological Phenomena Cohort Studies Fasting / blood Female Genotype Humans Life Style Male Middle Aged Physical Education and Training* Physical Fitness* Sex Factors* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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1R15AG 1367-01A1/AG/NIA NIH HHS; R15 AG013767-02/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
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