| Apolipoprotein E genotype and mortality in Southern European and Anglo-Celt patients with type 2 diabetes: the Fremantle Diabetes Study. | |
| | |
MedLine Citation:
|
PMID: 20693183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine whether cardiac and all-cause mortality are lower in Southern European (SE) patients than in Anglo-Celt (AC) patients with type 2 diabetes in an urban Australian setting, and, if so, whether ethnicity-specific differences in apolipoprotein E (APOE) genotypes are contributory. DESIGN: Longitudinal observational cohort study. METHODS: We analysed detailed data from 1057 patients from the community-based Fremantle Diabetes Study, 238 were of an SE migrant background and 819 of AC ethnicity. Cox proportional hazards modelling was used to identify independent predictors of cardiac and all-cause mortality. RESULTS: During 9.8±3.5 years of follow-up, 411 (38.9%) participants died, 161 (39.2%) from cardiac causes. Significant positive baseline independent predictors of cardiac death were age, male gender, coronary heart disease, cerebrovascular disease, peripheral arterial disease, retinopathy and peripheral neuropathy (P≤0.004), while maternal history of diabetes was protective (P=0.014). After adjusting for these variables, APOE4 carriage was predictive (hazard ratio (95% confidence interval) 1.61 (1.01-2.58); P=0.048). SE ethnicity did not add significantly to the model either as a single variable or as an interaction term with APOE4 carriage (P≥0.86). Significant independent predictors of all-cause mortality were age, male gender, smoking, coronary heart disease, cerebrovascular disease, peripheral arterial disease, retinopathy, peripheral neuropathy and microalbuminuria (P≤0.047), while overweight/obesity, lipid-lowering therapy and recent exercise were protective (P≤0.008). APOE4 carriage, SE ethnicity and their interaction did not add to the model (P≥0.32). CONCLUSIONS: SE ethnicity does not confer an independent survival advantage in community-based Australian type 2 diabetic patients, but APOE4 carriers are at higher risk of cardiac death. |
| | |
Authors:
|
Wendy A Davis; Eunice Chin; Adelle Jee; Jen Martins; David G Bruce; John Beilby; Timothy M E Davis |
Related Documents
:
|
16715613 - Mortality rates due to diabetes in a selected urban south indian population--the chenna... 9007483 - Early mortality in childhood diabetes in austria--a population based cohort study. 2872983 - Antibodies to pancreatic hormones in diabetics treated before 1964 and after 1974. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-06 |
Journal Detail:
|
Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 163 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-17 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 559-64 Citation Subset: IM |
Affiliation:
|
School of Medicine and Pharmacology, Fremantle Hospital, University of Western Australia, Fremantle, Western Australia, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Apolipoproteins E / genetics* Australia Diabetes Mellitus, Type 2 / ethnology, genetics*, mortality* European Continental Ancestry Group Female Genotype Humans Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sevoflurane and propofol anaesthesia differentially modulate the effects of epinephrine and norepine...
Next Document: Decision Trees as a simple-to-use and reliable tool to identify individuals with impaired glucose me...