| Apolipoprotein E genotype in matched men and women with coronary heart disease. | |
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MedLine Citation:
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PMID: 16254254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apolipoprotein E (apo E) plays an important role in lipid metabolism and its polymorphism may be a risk determinant of coronary heart disease (CHD). Since evidence suggested a gender-specific effect of apo E polymorphism, we studied the influence of gender-specific interaction of the polymorphism on CHD. From a total of 463 Greek Caucasians (314 men and 149 postmenopausal women) with angiographically documented CHD, we selected 79 women (68+/- 9 yr old) and 79 men (66+/- 9 yr old) who were matched for clinical characteristics. Apo E genotyping was performed by PCR and RFLP analysis. Biochemical parameters were also measured. The results were as follows: the E3/3 genotype occurred in 78.5% of the patients, followed by E3/4, E2/3, E2/4, and E4/4 genotypes, which occurred in 9.5%, 9.5%, 1.9%, and 0.6% of the patients, respectively. No significant differences were observed in the apo E allele or apo E genotype distributions between the matched Greek men and women with CHD. The E3/3 men patients were more frequently part of a family with a history of CHD, compared to women (p=0.035). |
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Authors:
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Genovefa D Kolovou; Katherine K Anagnostopoulou; Klelia D Salpea; Demosthenes B Panagiotakos; Ioannis S Hoursalas; Marios A Cariolou; Katerina Koniavitou; Dennis V Cokkinos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of clinical and laboratory science Volume: 35 ISSN: 0091-7370 ISO Abbreviation: Ann. Clin. Lab. Sci. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-10-28 Completed Date: 2006-02-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0410247 Medline TA: Ann Clin Lab Sci Country: United States |
Other Details:
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Languages: eng Pagination: 391-6 Citation Subset: IM |
Affiliation:
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Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece. genkolovou@mail.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Apolipoproteins E / genetics* Coronary Disease / ethnology, genetics*, pathology European Continental Ancestry Group Female Genetic Predisposition to Disease* Genotype Greece / epidemiology Humans Male Polymorphism, Genetic / genetics* Postmenopause Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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