Document Detail


Apolipoprotein E genotype in matched men and women with coronary heart disease.
MedLine Citation:
PMID:  16254254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apolipoprotein E (apo E) plays an important role in lipid metabolism and its polymorphism may be a risk determinant of coronary heart disease (CHD). Since evidence suggested a gender-specific effect of apo E polymorphism, we studied the influence of gender-specific interaction of the polymorphism on CHD. From a total of 463 Greek Caucasians (314 men and 149 postmenopausal women) with angiographically documented CHD, we selected 79 women (68+/- 9 yr old) and 79 men (66+/- 9 yr old) who were matched for clinical characteristics. Apo E genotyping was performed by PCR and RFLP analysis. Biochemical parameters were also measured. The results were as follows: the E3/3 genotype occurred in 78.5% of the patients, followed by E3/4, E2/3, E2/4, and E4/4 genotypes, which occurred in 9.5%, 9.5%, 1.9%, and 0.6% of the patients, respectively. No significant differences were observed in the apo E allele or apo E genotype distributions between the matched Greek men and women with CHD. The E3/3 men patients were more frequently part of a family with a history of CHD, compared to women (p=0.035).
Authors:
Genovefa D Kolovou; Katherine K Anagnostopoulou; Klelia D Salpea; Demosthenes B Panagiotakos; Ioannis S Hoursalas; Marios A Cariolou; Katerina Koniavitou; Dennis V Cokkinos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  35     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-28     Completed Date:  2006-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  IM    
Affiliation:
Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece. genkolovou@mail.gr
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MeSH Terms
Descriptor/Qualifier:
Aged
Apolipoproteins E / genetics*
Coronary Disease / ethnology,  genetics*,  pathology
European Continental Ancestry Group
Female
Genetic Predisposition to Disease*
Genotype
Greece / epidemiology
Humans
Male
Polymorphism, Genetic / genetics*
Postmenopause
Sex Factors
Chemical
Reg. No./Substance:
0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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