Document Detail

Apolipoprotein E genotype in matched men and women with coronary heart disease.
MedLine Citation:
PMID:  16254254     Owner:  NLM     Status:  MEDLINE    
Apolipoprotein E (apo E) plays an important role in lipid metabolism and its polymorphism may be a risk determinant of coronary heart disease (CHD). Since evidence suggested a gender-specific effect of apo E polymorphism, we studied the influence of gender-specific interaction of the polymorphism on CHD. From a total of 463 Greek Caucasians (314 men and 149 postmenopausal women) with angiographically documented CHD, we selected 79 women (68+/- 9 yr old) and 79 men (66+/- 9 yr old) who were matched for clinical characteristics. Apo E genotyping was performed by PCR and RFLP analysis. Biochemical parameters were also measured. The results were as follows: the E3/3 genotype occurred in 78.5% of the patients, followed by E3/4, E2/3, E2/4, and E4/4 genotypes, which occurred in 9.5%, 9.5%, 1.9%, and 0.6% of the patients, respectively. No significant differences were observed in the apo E allele or apo E genotype distributions between the matched Greek men and women with CHD. The E3/3 men patients were more frequently part of a family with a history of CHD, compared to women (p=0.035).
Genovefa D Kolovou; Katherine K Anagnostopoulou; Klelia D Salpea; Demosthenes B Panagiotakos; Ioannis S Hoursalas; Marios A Cariolou; Katerina Koniavitou; Dennis V Cokkinos
Related Documents :
22456854 - Children's gender and parents' color preferences.
22757734 - Androgens in women before and after the menopause and post bilateral oophorectomy: clin...
15302104 - Association of hypo-responsive toll-like receptor 4 variants with risk of myocardial in...
22639964 - Predictors of condom use and refusal among the population of free state province in sou...
16140634 - The role of early life environmental risk factors in parkinson disease: what is the evi...
14972074 - Assessment of the nutritional risk of >53-year-old men and women in taiwan.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  35     ISSN:  0091-7370     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-28     Completed Date:  2006-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  IM    
Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Apolipoproteins E / genetics*
Coronary Disease / ethnology,  genetics*,  pathology
European Continental Ancestry Group
Genetic Predisposition to Disease*
Greece / epidemiology
Polymorphism, Genetic / genetics*
Sex Factors
Reg. No./Substance:
0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The autopsy in a tertiary teaching hospital in Brazil.
Next Document:  Histone deacetylase inhibitor pharmacodynamic analysis by multiparameter flow cytometry.