| Apolipoprotein E distribution among different plaque types in Alzheimer's disease: implications for its role in plaque progression. | |
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MedLine Citation:
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PMID: 8875468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to determine the pattern of ApoE immunoreactivity in mesial temporal lobe tissue from 12 Alzheimer patients, age 66-88, and to determine the distribution of this immunoreactivity among different plaque types representing hypothesized stages of plaque evolution. In these patients, the cortical area of ApoE immunoreactivity was 30% that of beta-amyloid. Only 6% of diffuse non-neuritic amyloid deposits were even weakly ApoE immunoreactive (ApoE+). This is in contrast to our previous demonstration that microglia overexpressing interleukin-1 (IL-1) are present in most diffuse non-neuritic deposits. Eighty-three per cent of diffuse neuritic plaques and 86% of dense-core neuritic plaques were highly ApoE+, consistent with IL-1-induced astrocyte activation and synthesis of ApoE resulting in the appearance of ApoE immunoreactivity in neuritic plaques. Dense-core non-neuritic ('burned out') plaques were only rarely (6%) ApoE+. These results, together with the known trophic and toxic effects of ApoE on neurites, suggest that plaque-associated ApoE contributes to the formation of overgrown degenerating (dystrophic) neurites in plaques. However, the fact that some neuritic plaques are not ApoE+ suggests contributions by additional trophic and toxic factors. Our results are also consistent with a role for ApoE in the condensation of diffuse amyloid deposits into a beta-pleated-sheet form that occurs concomitant with dystrophic neurite formation in the neuritic beta-amyloid plaques of Alzheimer's disease. |
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Authors:
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J G Sheng; R E Mrak; W S Griffin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuropathology and applied neurobiology Volume: 22 ISSN: 0305-1846 ISO Abbreviation: Neuropathol. Appl. Neurobiol. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-01-23 Completed Date: 1997-01-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7609829 Medline TA: Neuropathol Appl Neurobiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 334-41 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / metabolism*, pathology* Apolipoproteins E / metabolism* Blotting, Western Female Humans Image Processing, Computer-Assisted Immunohistochemistry Male Neurites / ultrastructure Temporal Lobe / metabolism*, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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AG10208/AG/NIA NIH HHS; AG12411/AG/NIA NIH HHS; NS27414/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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