| Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by diet-induced obesity. | |
| | |
MedLine Citation:
|
PMID: 20633710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The long prevailing view that obesity is generally associated with beneficial effects on the skeleton has recently been challenged. Apolipoprotein E (apoE) is known to influence both adipose tissue and bone. The goal of the current study was to examine the impact of apoE on the development of fat mass and bone mass in mice under conditions of diet-induced obesity (DIO). Four week-old male C57BL/6 (WT) and apoE-deficient (apoE(-/-)) mice received a control or a diabetogenic high-fat diet (HFD) for 16 weeks. The control-fed apoE(-/-) animals displayed less total fat mass and higher lumbar trabecular bone volume (BV/TV) than WT controls. When stressed with HFD to induce obesity, apoE(-/-) mice had a lower body weight, lower serum glucose, insulin and leptin levels and accumulated less white adipose tissue mass at all sites including bone marrow. While WT animals showed no significant change in BV/TV and bone formation rate (BFR), apoE deficiency led to a decrease of BV/TV and BFR when stressed with HFD. Bone resorption parameters were not affected by HFD in either genotype. Taken together, under normal dietary conditions, apoE-deficient mice acquire less fat mass and more bone mass than WT littermates. When stressed with HFD to develop DIO, the difference of total body fat mass becomes larger and the difference of bone mass smaller between the genotypes. We conclude that apoE is involved in an inverse regulation of bone mass and fat mass in growing mice and that this effect is modulated by diet-induced obesity. |
| | |
Authors:
|
Alexander Bartelt; F Timo Beil; Thorsten Schinke; Kerstin Roeser; Wolfgang Ruether; Joerg Heeren; Andreas Niemeier |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-12 |
Journal Detail:
|
Title: Bone Volume: 47 ISSN: 1873-2763 ISO Abbreviation: Bone Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-13 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8504048 Medline TA: Bone Country: United States |
Other Details:
|
Languages: eng Pagination: 736-45 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Biochemistry and Molecular Biology II: Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. abartelt@uke.uni-hamburg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipocytes
/
drug effects,
metabolism,
pathology Adipose Tissue / drug effects, metabolism, pathology* Animals Apolipoproteins E / deficiency, metabolism* Blood Glucose / metabolism Bone Marrow Cells / drug effects, metabolism, pathology Bone Remodeling / drug effects Cell Proliferation / drug effects Diet* Dietary Fats / administration & dosage, pharmacology Epididymis / drug effects, metabolism, pathology Insulin / metabolism Leptin / blood Lipids / blood Male Mice Mice, Inbred C57BL Obesity / blood, metabolism*, pathology*, physiopathology Organ Size / drug effects Spine / metabolism, pathology*, physiopathology Subcutaneous Tissue / drug effects, metabolism, pathology Viscera / drug effects, metabolism, pathology Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins E; 0/Blood Glucose; 0/Dietary Fats; 0/Leptin; 0/Lipids; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stiffness of the endplate boundary layer and endplate surface topography are associated with brittle...
Next Document: Therapy for CAPS.