Document Detail


Apolipoprotein E is associated with blood lipids and inflammation in Taiwanese older adults.
MedLine Citation:
PMID:  21840004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymorphisms of the apolipoprotein E gene (ApoE) have been associated with health and longevity. Numerous studies have linked ApoE to health outcomes including cardiovascular disease and mortality, but far fewer studies have examined the relationship of ApoE to other biological markers of health. This study investigates the relationship between ApoE and mortality, as well as ApoE and a set of biomarkers related to cardiovascular and immune function, in a population-based sample of Taiwanese adults ages 54+. ApoE £2 carriers were less likely to have at-risk levels of high-density lipoprotein (HDL-C) and total cholesterol (total-C) than non-carriers (odds ratio [OR] 0.45, 95% confidence interval [CI] 0.25-0.83 and OR 0.45, 95% CI 0.29-0.71, respectively). ApoE £4 carriers were less likely to have elevated levels of C-reactive protein (CRP) than non-carriers (OR 0.62, 95% CI 0.39-0.96). ApoE genotype was not, however, associated with mortality after 8 years of follow-up. Our findings confirm the association between ApoE £2and cholesterol levels, suggesting a potential protective effect of ApoE £2 on blood lipids. They also contribute to reports on the relationship between ApoE £4 carrier status and lower CRP levels.
Authors:
Sarinnapha Vasunilashorn; Dana A Glei; Chia-Ying Lan; Ron Brookmeyer; Maxine Weinstein; Noreen Goldman
Related Documents :
18197444 - The association between past chlamydia pneumoniae infection and markers of chronic infl...
15655034 - Prevalence of obesity in great britain.
8385074 - Gender differences in obesity-related cardiovascular disease risk factors among partici...
7855114 - Cardiovascular risk factors in adolescence: prevalence and familial aggregation.
21190974 - High rate of persistent hypothyroidism in a large-scale prospective study of postpartum...
3385704 - Late complications of the estes operation for tubal infertility. a case report.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-07-27
Journal Detail:
Title:  Atherosclerosis     Volume:  219     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-01     Completed Date:  2012-02-27     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  349-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Apolipoproteins E / blood,  genetics*
Biological Markers / blood
C-Reactive Protein / metabolism
Cholesterol / blood
Female
Follow-Up Studies
Genotype
Humans
Inflammation / blood,  genetics*
Lipids / blood*
Male
Middle Aged
Polymorphism, Genetic
Risk Factors
Survival Analysis
Taiwan / epidemiology
Grant Support
ID/Acronym/Agency:
R01 AG016661/AG/NIA NIH HHS; R01 AG016661-13/AG/NIA NIH HHS; R01 AG016790/AG/NIA NIH HHS; R01 AG016790/AG/NIA NIH HHS; R01 AG016790-08/AG/NIA NIH HHS; R01 AG16661/AG/NIA NIH HHS; R24 HD047879/HD/NICHD NIH HHS; R24 HD047879/HD/NICHD NIH HHS; R24 HD047879-06/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Biological Markers; 0/Lipids; 9007-41-4/C-Reactive Protein; 97C5T2UQ7J/Cholesterol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact...
Next Document:  ABCA1 impacts athero-thrombotic risk and 10-year survival in a contemporary secondary prevention set...