| Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study. | |
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MedLine Citation:
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PMID: 20729559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although much is known about the effect of Apolipoprotein E (APOE) alleles on fasting lipid concentrations, less is known about the effect of APOE alleles on postprandial triglyceridemia or the triglyceride response to fenofibrate. METHODS AND RESULTS: We evaluated the effects of the APOE locus on fasting and postprandial triglyceride concentrations as part of the Genetics of Lipid Lowering and Diet Network (GOLDN) study. Participants were evaluated after a high-fat meal challenge before (n=1072) and after 3 weeks of daily treatment with 160 mg of fenofibrate (n=738). Mixed models adjusted for sex, age, waist circumference, and family relationship were used to examine the association of the ε4 carrier and ε2 carrier status versus ε3 homozygotes with fasting triglycerides and the area under the curve (AUC) for triglycerides during the high-fat meal challenge. Compared with the ε3/ε3 genotype, ε2 carriers had on average higher fasting triglyceride concentrations (130.5 mg/dL versus 109.3 mg/dL, P<0.001). After fenofibrate treatment, the APOE genotype differences persisted in the fasting state (ε2 carriers: 85.1 mg/dL versus ε3/ε3: 75.9 mg/dL, P<0.05). Carriers of the ε4 allele had significantly higher fasting triglyceride concentrations only prefenofibrate (120.9 mg/dL versus 109.3 mg/dL, P=0.008). APOE alleles did not have an effect on response to fenofibrate. Postprandial triglycerides were significantly higher for ε2 carriers versus ε3 homozygotes (but not ε4 carriers) both before and after fenofibrate treatment (P=0.01 and P=0.005, respectively). CONCLUSIONS: APOE polymorphisms are important determinants of triglyceride concentrations, especially in the fasting state. |
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Authors:
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Marguerite R Irvin; Edmond K Kabagambe; Hemant K Tiwari; Laurence D Parnell; Robert J Straka; Michael Tsai; Jose M Ordovas; Donna K Arnett |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-21 |
Journal Detail:
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Title: Circulation. Cardiovascular genetics Volume: 3 ISSN: 1942-3268 ISO Abbreviation: Circ Cardiovasc Genet Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-20 Completed Date: 2011-01-31 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 101489144 Medline TA: Circ Cardiovasc Genet Country: United States |
Other Details:
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Languages: eng Pagination: 462-7 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, University of Alabama at Birmingham, USA. irvinr@uab.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoproteins E / genetics* Dietary Fats / metabolism Fasting Female Fenofibrate / therapeutic use* Genotype Humans Hyperlipidemias / drug therapy* Hypolipidemic Agents / therapeutic use* Middle Aged Polymorphism, Genetic* Postprandial Period / physiology* Triglycerides / blood* |
| Grant Support | |
ID/Acronym/Agency:
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T32NS054584/NS/NINDS NIH HHS; U01 HL072524-04/HL/NHLBI NIH HHS; U01HL072524-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Dietary Fats; 0/Hypolipidemic Agents; 0/Triglycerides; 49562-28-9/Fenofibrate |
| Comments/Corrections | |
Comment In:
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Circ Cardiovasc Genet. 2011 Feb;4(1):e5; author reply e6
[PMID:
21325156
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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