Document Detail


Apolipoprotein E (APOE), PARKIN and catechol-O-methyltransferase (COMT) genes and susceptibility to sporadic Parkinson's disease in Finland.
MedLine Citation:
PMID:  12270650     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have demonstrated that genetic factors modify susceptibility to sporadic Parkinson's disease (PD). So far the results of candidate gene studies have been conflicting. It has been suggested that polymorphisms in apolipoprotein E (APOE), PARKIN and catechol-O-methyltransferase (COMT) genes might increase the risk of PD. We studied 147 Finnish non-demented patients with sporadic PD and 137 controls. APOE epsilon allele and genotype frequencies in PD patients did not differ significantly from controls. Three single nucleotide polymorphisms of the PARKIN gene and an intronic and an exonic (Val158Met) polymorphism of the COMT gene were studied. None of these polymorphisms showed association with PD in our series. In contrast to reports in oriental populations, our results do not support a major role of APOE, PARKIN and COMT polymorphisms in PD susceptibility in the Finnish population.
Authors:
J Eerola; J Launes; O Hellström; P J Tienari
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  330     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-24     Completed Date:  2002-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  296-8     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Affiliation:
Department of Neurology, Helsinki University Central Hospital, and University of Helsinki, Biomedicum-Helsinki, Neuroscience Programme C524, PL 700, Haartmaninkatu 8, Helsinki, Finland. johanna.eerola@helsinki.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Apolipoproteins E / genetics*
Catechol O-Methyltransferase / genetics*
Female
Finland
Genetic Predisposition to Disease*
Genotype
Humans
Ligases / genetics*
Male
Middle Aged
Parkinson Disease / genetics*
Polymorphism, Genetic*
Ubiquitin-Protein Ligases*
Chemical
Reg. No./Substance:
0/Apolipoproteins E; EC 2.1.1.6/Catechol O-Methyltransferase; EC 6.-/Ligases; EC 6.3.2.19/Ubiquitin-Protein Ligases; EC 6.3.2.19/parkin protein

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