| Apolipoprotein B, non-HDL cholesterol and LDL cholesterol for identifying individuals at increased cardiovascular risk. | |
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MedLine Citation:
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PMID: 21091808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To compare apolipoprotein B (apoB), non-high-density lipoprotein-cholesterol (non-HDL-c) and low-density lipoprotein-cholesterol (LDL-c) for identifying individuals with a deteriorated cardiovascular (CV) risk profile, including a panel of subclinical atherosclerosis measurements and prevalent cardiovascular disease (CVD) in a Dutch population-based cohort. METHODS: Clinical and biochemical measurements and a panel of noninvasive parameters of subclinical atherosclerosis were determined in 1517 individuals, aged 50-70 years. RESULTS: Both men and women with increasing levels of apoB and non-HDL-c were more obese, had higher blood pressure and fasting glucose levels, and a more atherogenic lipid profile. Furthermore, compared to the reference group (composed of those with apoB, non-HDL-c and LDL-c levels in the bottom quartiles), participants with high apoB and high non-HDL-c levels had a lower ankle-brachial index at rest (-3.5% and -3.1%, respectively) and after exercise (-6.3% and -4.7%, respectively), a thicker near wall (+4.8% and +4.2%, respectively), far wall (both +6.2%), and mean intima-media thickness (+5.7% and +5.3%, respectively) and more plaques (+54.2% and +54.3%, respectively). In addition, they also showed increased stiffness parameters (e.g. pulse wave velocity both +3.6%). Less clear differences in CV risk profile and subclinical atherosclerosis parameters were observed when participants were stratified by LDL-c level. Furthermore, apoB but not LDL-c detected prevalent CVD, and non-HDL-c only detected prevalent CVD in men. The discriminatory power for prevalent CVD expressed as area under the receiver operating characteristic curve was 0.60 (P < 0.001) for apoB, 0.57 (P = 0.001) for non-HDL-c and 0.54 (P = 0.108) for LDL-c. CONCLUSION: Our data support the use of first apoB and secondly non-HDL-c above LDL-c for identifying individuals from the general population with a compromised CV phenotype. |
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Authors:
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S Holewijn; M den Heijer; D W Swinkels; A F H Stalenhoef; J de Graaf |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of internal medicine Volume: 268 ISSN: 1365-2796 ISO Abbreviation: J. Intern. Med. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: England |
Other Details:
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Languages: eng Pagination: 567-77 Citation Subset: IM |
Copyright Information:
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© 2010 The Association for the Publication of the Journal of Internal Medicine. |
Affiliation:
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Division of Vascular Medicine, Department of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands. s.holewijn@aig.umcn.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Apolipoproteins B / blood* Atherosclerosis / blood, diagnosis, pathology, physiopathology Biological Markers / blood Blood Glucose / metabolism Blood Pressure / physiology Cardiovascular Diseases / blood, diagnosis*, physiopathology Cholesterol / blood* Cholesterol, HDL / blood Cholesterol, LDL / blood Female Humans Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins B; 0/Biological Markers; 0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 57-88-5/Cholesterol |
| Comments/Corrections | |
Comment In:
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J Intern Med. 2010 Dec;268(6):549-51
[PMID:
21091807
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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