Document Detail


Apolipoprotein B-containing lipoprotein subclasses as risk factors for cardiovascular disease in patients with rheumatoid arthritis.
MedLine Citation:
PMID:  22337612     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to explore whether nontraditional risk factors, such as apolipoprotein C-III (Apo C-III) and its corresponding Apo B lipoprotein (Lp) subclasses, contribute to the risk of cardiovascular disease in rheumatoid arthritis (RA) patients.
METHODS: Apolipoprotein and lipoproteins were measured in 152 RA patients by immunoturbidimetric procedures, electroimmunoassay, and immunoprecipitation. Patients had a coronary artery calcium (CAC) score assessed at baseline and at year 3. Differences in the CAC scores between baseline and year 3 were calculated and dichotomized at 0, where patients with a difference score >0 were denoted as progressors and the rest were denoted as nonprogressors. Differences between means were tested with a 2-sided independent Student's t-test with Satterthwaite's adjustment. Proportion differences were tested with a chi-square test. Multiple logistic regression was performed to assess the relationship between apolipoprotein and lipoprotein levels and the dichotomized CAC score.
RESULTS: Progressors accounted for almost 60% of the cohort. Progressors had significantly higher levels of triglycerides, very low-density lipoprotein (VLDL) cholesterol, total cholesterol/high-density lipoprotein (HDL), triglycerides/HDL, Apo B, LpA-II:B:C:D:E, LpB:C, Apo B/Apo A-I, Apo C-III, and Apo C-III-heparin precipitate than the nonprogressors. After adjusting for age, sex, statin use (yes/no), and hypertension (yes/no), significant risk factors of progressors were total cholesterol, triglycerides, VLDL cholesterol, LDL cholesterol, Apo B, LpB:C, Apo C-III, and Apo B/Apo A-I.
CONCLUSION: Apo C-III-containing Apo B lipoprotein subclasses were found to be significantly elevated in progressors compared to nonprogressors. Many of these same lipoproteins were found to be associated with an increase in CAC scores among progressors. These lipoproteins may be considered new risk factors for progression of atherosclerosis in RA patients.
Authors:
N Knowlton; J A Wages; M B Centola; J Giles; J Bathon; C Quiroga; P Alaupovic
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis care & research     Volume:  64     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-28     Completed Date:  2012-10-23     Revised Date:  2013-10-22    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  993-1000     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
Affiliation:
Oklahoma Medical Research Foundation, Oklahoma City, OK, USA. n.knowlton@auckland.ac.nz
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Apolipoprotein C-III / blood*
Apolipoproteins B / blood*
Arthritis, Rheumatoid / blood,  complications*
Biological Markers / blood
Cardiovascular Diseases / blood,  epidemiology*
Cholesterol / blood
Cohort Studies
Female
Humans
Lipoproteins / blood*,  classification*
Lipoproteins, HDL / blood
Lipoproteins, VLDL / blood
Male
Middle Aged
Prospective Studies
Retrospective Studies
Risk Factors
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
AR-050026-01/AR/NIAMS NIH HHS; K23-AR-054112-01/AR/NIAMS NIH HHS; M01-RR-02719/RR/NCRR NIH HHS; OCAST AR-11-074/AR/NIAMS NIH HHS; R01 AR050026/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein C-III; 0/Apolipoproteins B; 0/Biological Markers; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, VLDL; 0/Triglycerides; 57-88-5/Cholesterol
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