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Apolipoprotein B-48 to Triglyceride Ratio Is a Novel and Useful Marker for Detection of Type III Hyperlipidemia after Antihyperlipidemic Intervention.
MedLine Citation:
PMID:  22878701     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim: Remnant lipoproteins are atherogenic and are accumulated in patients with type III hyperlipidemia (HL). Although type III HL is diagnosed by phenotyping apolipoprotein (apo) E, this procedure is time-consuming and inconvenient for routine clinical use. Clinical indices for screening type III HL in untreated HL patients have been proposed; however, in clinical settings, HL patients are promptly treated with lipid-lowering agents without diagnosing the underlying cause. We investigated whether existing clinical indices for screening type III HL as well as the apo B-48/triglyceride (TG) ratio, which was suggested to be related to the accumulation of small chylomicron (CM) remnants, are useful after the initiation of lipid-lowering therapies.Methods: In 25 normolipidemic subjects and 191 treated HL patients (type I, n =6; IIa, 62; IIb, 66; III, 12; IV, 22; and V, 23) from Osaka University Hospital and related hospitals, fasting low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TG, and apolipoproteins were measured and clinical indices were evaluated statistically.Results: Apo B-48 levels were significantly higher in patients with type I, III, and V HL, and TG levels were significantly higher in patients with type I and V HL. The apo B-48/TG ratio was significantly higher only in patients with type III HL compared with other types of HL (p<0.001), and was statistically significant among the other clinical indices (AUC-ROC value, 0.895; cut-off value, 0.110).Conclusion: The apo B-48/TG ratio is a novel and useful marker for detecting type III HL even after the initiation of lipid-lowering interventions.
Authors:
Miyako Yuasa-Kawase; Daisaku Masuda; Rika Kitazume-Taneike; Taiji Yamashita; Ryota Kawase; Hajime Nakaoka; Miwako Inagaki; Kazuhiro Nakatani; Kazumi Tsubakio-Yamamoto; Tohru Ohama; Yumiko Toyama-Nakagawa; Makoto Nishida; Masato Ishigami; Mieko Saito; Masaaki Eto; Akifumi Matsuyama; Issei Komuro; Shizuya Yamashita
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-09
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  -     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.
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