Document Detail

Apolipoprotein AI is a serum and tissue marker of liver fibrosis in alcoholic patients.
MedLine Citation:
PMID:  2513736     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to assess the specific correlation of apolipoprotein-AI to hepatic fibrosis in alcoholic patients. Four hundred eighty two patients were prospectively included with serum measurement of apolipoprotein-AI within 10 days before liver biopsy. Pathologic features were semiquantitatively assessed by two observers. In 28 patients liver biopsy was used for histomorphometric assessment of fibrosis and immunohistochemical labeling of apolipoprotein-AI. Serum apolipoprotein-AI was negatively correlated to semiquantitative score of fibrosis (r = -0.50; p less than 0.001), independently of the scores of steatosis and alcoholic hepatitis (r = -0.44; p less than 0.001) and of the value of serum albumin, bilirubin, and prothrombin time (r = -0.22; p less than 0.001) and independently of the nutritional parameters (r = -0.29; p less than 0.009). The mean value of apolipoprotein-AI decreased according to the grade of fibrosis from 220 +/- 6 mg/dl (mean +/- SEM) to 110 +/- 8 mg/dl. Serum apolipoprotein-AI was negatively correlated to the percentage of fibrosis (r = -0.70; p less than 0.001) in the biopsies morphometrically assessed. The labeling was superimposed to the extracellular matrix. In conclusion, this study shows that decrease of apolipoprotein-AI is a serum and tissue marker of liver fibrosis independently of steatosis, alcoholic hepatitis, liver function tests, and nutritional parameters.
P Bedossa; T Poynard; A Abella; A Aubert; J P Pignon; S Naveau; R Leluc; G Lemaigre; E D Martin; J C Chaput
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  13     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-02-02     Completed Date:  1990-02-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  829-33     Citation Subset:  IM    
Antoine Béclère Hospital, Clamart, France.
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MeSH Terms
Apolipoprotein A-I
Apolipoproteins A / analysis*
Apolipoproteins B / analysis
Biological Markers / analysis
Liver Cirrhosis, Alcoholic / diagnosis*,  metabolism
Liver Function Tests
Middle Aged
Portal System / pathology
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoproteins A; 0/Apolipoproteins B; 0/Biological Markers

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