| Apolipoprotein AI is a serum and tissue marker of liver fibrosis in alcoholic patients. | |
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MedLine Citation:
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PMID: 2513736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to assess the specific correlation of apolipoprotein-AI to hepatic fibrosis in alcoholic patients. Four hundred eighty two patients were prospectively included with serum measurement of apolipoprotein-AI within 10 days before liver biopsy. Pathologic features were semiquantitatively assessed by two observers. In 28 patients liver biopsy was used for histomorphometric assessment of fibrosis and immunohistochemical labeling of apolipoprotein-AI. Serum apolipoprotein-AI was negatively correlated to semiquantitative score of fibrosis (r = -0.50; p less than 0.001), independently of the scores of steatosis and alcoholic hepatitis (r = -0.44; p less than 0.001) and of the value of serum albumin, bilirubin, and prothrombin time (r = -0.22; p less than 0.001) and independently of the nutritional parameters (r = -0.29; p less than 0.009). The mean value of apolipoprotein-AI decreased according to the grade of fibrosis from 220 +/- 6 mg/dl (mean +/- SEM) to 110 +/- 8 mg/dl. Serum apolipoprotein-AI was negatively correlated to the percentage of fibrosis (r = -0.70; p less than 0.001) in the biopsies morphometrically assessed. The labeling was superimposed to the extracellular matrix. In conclusion, this study shows that decrease of apolipoprotein-AI is a serum and tissue marker of liver fibrosis independently of steatosis, alcoholic hepatitis, liver function tests, and nutritional parameters. |
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Authors:
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P Bedossa; T Poynard; A Abella; A Aubert; J P Pignon; S Naveau; R Leluc; G Lemaigre; E D Martin; J C Chaput |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: 13 ISSN: 0145-6008 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-02-02 Completed Date: 1990-02-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 829-33 Citation Subset: IM |
Affiliation:
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Antoine Béclère Hospital, Clamart, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoprotein A-I Apolipoproteins A / analysis* Apolipoproteins B / analysis Biological Markers / analysis Female Humans Immunohistochemistry Liver Cirrhosis, Alcoholic / diagnosis*, metabolism Liver Function Tests Male Middle Aged Portal System / pathology |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoproteins A; 0/Apolipoproteins B; 0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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