Document Detail


ApoVLDL of the Watanabe Heritable Hyperlipidemic rabbit and the cholesterol-fed rabbit.
MedLine Citation:
PMID:  6726079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Watanabe Heritable Hyperlipidemic rabbit (WHHL rabbit) and the cholesterol-fed rabbit have been reported to show elevations of very low density (VLDL), intermediate density (IDL), and low density lipoproteins (LDL), and a broad-beta band on agarose-gel electrophoresis. We have studied the lipid and lipoprotein composition of WHHL rabbits and cholesterol-fed rabbits using ultracentrifugal analysis and isoelectric focusing. The total cholesterol (TC)/triglyceride (TG) ratios of VLDL, IDL, and LDL in WHHL rabbits were slightly elevated, but almost normal compared with those of cholesterol-fed rabbits, whose TC/TG ratios were markedly elevated compared with normolipidemic rabbits. ApoVLDL of WHHL rabbits showed no compositional changes in apoE and apoC isoforms, and no marked changes in the apoE/apoC ratios. But apoVLDL of cholesterol-fed rabbits showed a significant decrease of apoC-III, a significant increase of apoC-V, and marked elevation of the apoE/apoC ratio. We conclude that serum lipoprotein compositions in the WHHL rabbit were normal, while the lipoprotein lipid and apolipoprotein composition in the WHHL rabbit are different from those in cholesterol-fed rabbits.
Authors:
T Wakasugi; H Mabuchi; Y Sakai; T Sakai; A Yoshimura; A Watanabe; J Koizumi; S Miyamoto; R Takeda; Y Watanabe
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of lipid research     Volume:  25     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-06-27     Completed Date:  1984-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  246-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholesterol / blood
Cholesterol, Dietary / pharmacology*
Disease Models, Animal
Humans
Hyperlipidemias / blood*,  genetics
Isoelectric Focusing
Lipoproteins / blood,  isolation & purification
Male
Rabbits
Species Specificity
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Lipoproteins; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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