Document Detail


ApoE genotype and family history in patients with dementia and cognitively intact spousal controls.
MedLine Citation:
PMID:  19372276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To test that a positive family history and ApoE e4 genotype are prevalent among dementia patients with onset before 70 years of age compared with healthy spousal controls. METHODS: A total of 210 patients with dementia and 82 spousal control participants. Neuropsychiatric examination, Consortium to establish a registry on Alzheimer's disease test battery, Clock-drawing Test, and ApoE genotyping were performed in patients and controls. RESULTS: Of the 131 patients with Alzheimer dementia, 25 were homozygous for Apo e4. Among dementia patients with a positive family history (n = 83), homozygosity for the Apo e4 genotype was found in 19 (22.9%). A positive family history was highest among Apo e4 homozygous Alzheimer dementia patients (72.0%) and lowest among the cognitively normal spousal controls (9.3%). CONCLUSIONS: In our sample of patients with Alzheimer dementia, approximately 3 of 4 (72.0%) were homozygous for the genotype Apo e4 when they had a positive family history.
Authors:
Maria Zintl; Gerd Schmitz; Göran Hajak; Hans-Hermann Klünemann
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Publication Detail:
Type:  Journal Article     Date:  2009-04-16
Journal Detail:
Title:  American journal of Alzheimer's disease and other dementias     Volume:  24     ISSN:  1938-2731     ISO Abbreviation:  Am J Alzheimers Dis Other Demen     Publication Date:    2009 Aug-Sep
Date Detail:
Created Date:  2009-08-05     Completed Date:  2009-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101082834     Medline TA:  Am J Alzheimers Dis Other Demen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  349-52     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, School of Medicine, Regensburg, Germany. maria.zintl@web.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / epidemiology*,  genetics*
Apolipoprotein E2 / genetics
Apolipoprotein E3 / genetics
Apolipoprotein E4 / genetics
Apolipoproteins E / genetics*
Family Health
Female
Genetic Predisposition to Disease / epidemiology
Genotype
Heterozygote
Homozygote
Humans
Male
Middle Aged
Neuropsychological Tests
Spouses*
Chemical
Reg. No./Substance:
0/Apolipoprotein E2; 0/Apolipoprotein E3; 0/Apolipoprotein E4; 0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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