Document Detail

ApoE controls the interface linking lipids and inflammation in atherosclerosis.
MedLine Citation:
PMID:  21968109     Owner:  NLM     Status:  MEDLINE    
Atherosclerosis is a chronic inflammatory disease of the arterial walls that often leads to myocardial infarction and/or stroke. Hypercholesterolemia and an imbalance of peripheral leukocyte counts, leading to arterial leukocyte infiltration, are considered independent risk factors for atherosclerosis. However, in this issue of the JCI, Murphy and colleagues identify a mechanistic link between hypercholesterolemia, leukocytosis, and the subsequent development of atherosclerotic lesions in mice. These findings could pave the way for the development of novel treatment strategies to control leukocyte homeostasis and atherosclerosis.
Christian Weber; Oliver Soehnlein
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Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  121     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-11-04     Completed Date:  2011-11-21     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3825-7     Citation Subset:  AIM; IM    
Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany.
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MeSH Terms
Apolipoproteins E / physiology*
Atherosclerosis / pathology*,  physiopathology*
Hematopoietic Stem Cells / pathology*,  physiology*
Monocytes / pathology*
Reg. No./Substance:
0/Apolipoproteins E
Comment On:
J Clin Invest. 2011 Oct;121(10):4138-49   [PMID:  21968112 ]

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