| ApoE and cholesterol in schizophrenia and bipolar disorder: comparison of grey and white matter and relation with APOE genotype. | |
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MedLine Citation:
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PMID: 20964956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Apolipoprotein E (apoE) and cholesterol play a critical role in synapse and myelin maintenance and integrity and are thus appealing candidates in the pathogenesis of schizophrenia and bipolar disorder. To explore the role of these 2 molecules, we quantified cholesterol and apoE levels in prefrontal grey and white matter in patients with schizophrenia, bipolar disorder and healthy controls. Furthermore, we investigated the relations between apoE and cholesterol levels and the APOE genotype. METHODS: We obtained dorsolateral prefrontal grey and white matter from the Stanley Medical Research Institute Brain Collection (schizophrenia n = 35, bipolar disorder n = 35 and controls n = 35). Cholesterol levels were quantified using high-pressure liquid chromatography, whereas apoE was measured by enzyme-linked immunosorbent assay. RESULTS: We found no significant differences in cholesterol or apoE levels among the groups. ApoE levels were higher in grey matter than in white matter in all groups; conversely, levels of cholesterol were higher in white matter than in grey matter. We observed a significant inverse correlation between apoE and cholesterol levels in both grey and white matter. Furthermore, in grey matter, apoE levels were significantly higher in APOE ε2 carriers compared with APOE ε3 or APOE ε4 carriers, with cholesterol levels following the opposite trend. Limitations: Limitations of our study include our inability to control for potential confounding variables and the small numbers of APOE ε2 and ε4 carriers in each group. CONCLUSION: Although large amounts of cholesterol are present in white matter, apoE expression is limited. The APOE genotype may play a role in the regulation of both cholesterol and apoE levels in grey matter. The impact of APOE polymorphisms on lipid homeostasis in people with psychiatric disorders warrants further investigation. |
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Authors:
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Fidel Vila-Rodriguez; William G Honer; Sheila M Innis; Cheryl L Wellington; Clare L Beasley |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of psychiatry & neuroscience : JPN Volume: 36 ISSN: 1488-2434 ISO Abbreviation: J Psychiatry Neurosci Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: 2011-04-21 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 9107859 Medline TA: J Psychiatry Neurosci Country: Canada |
Other Details:
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Languages: eng Pagination: 47-55 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of British Columbia, Vancouver, BC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alleles Apolipoproteins E / genetics*, metabolism Bipolar Disorder / genetics*, metabolism* Cholesterol / metabolism* Female Genotype Humans Male Middle Aged Nerve Fibers, Myelinated / metabolism* Nerve Fibers, Unmyelinated / metabolism* Prefrontal Cortex / metabolism Schizophrenia / genetics*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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MOP-14037//Canadian Institutes of Health Research; MOP-81112//Canadian Institutes of Health Research; NET-54013//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 57-88-5/Cholesterol |
| Comments/Corrections | |
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