Document Detail

Apnoea of immaturity. 1. A controlled trial of theophylline and face mask continuous positive airways pressure.
MedLine Citation:
PMID:  6753769     Owner:  NLM     Status:  MEDLINE    
A randomised controlled trial of theophylline versus face-mask continuous positive airways pressure (CPAP) treatment for recurrent apnoea of immaturity was carried out in 32 infants of 25 to 32 weeks' gestation. Continuous recording of electrocardiogram and impedence pneumogram added objective assessment to the nurses' observations for 11 courses of treatment. The CPAP group had more adverse perinatal factors but the frequency of apnoeic attacks before treatment was comparable. Infants given theophylline had a greater reduction in the incidence of prolonged apnoeic attacks, and this difference persisted after allowing for the effect of perinatal complications. Continuous recordings showed a greater reduction in episodes of bradycardia of less than or equal to 80/minute with theophylline. Five of 18 infants given theophylline needed intermittent positive pressure ventilation for apnoea compared with 12 of 14 given CPAP. The poor response in 17 of 32 infants suggests a need for a more effective method of preventing or treating apnoea in very immature babies, in whom adverse perinatal factors often coexist.
R A Jones
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  57     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-21     Completed Date:  1982-12-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  761-5     Citation Subset:  AIM; IM    
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MeSH Terms
Apnea / drug therapy,  therapy*
Clinical Trials as Topic
Infant, Newborn
Infant, Premature, Diseases / drug therapy,  therapy*
Monitoring, Physiologic
Positive-Pressure Respiration*
Random Allocation
Theophylline / therapeutic use*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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