Document Detail


Apnea of prematurity: II. Respiratory reflexes.
MedLine Citation:
PMID:  6739219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Airway obstruction is a cause of apnea in preterm infants. The activity of protective respiratory reflexes was determined in 18 preterm infants with apnea (mean of 32 episodes of more than 20 seconds duration per day) and in 18 neonates without apnea used as control subjects. This was done in order to elucidate the role of respiratory reflexes in apnea of prematurity. The infants were matched for birth weight (1,068 g v 1,065 g), gestational age (30.2 weeks v 30.2 weeks), and postnatal age (8.6 days v 8.3 days). The airway occlusion technique was used to determine the inspiratory prolongation of the occluded breath and the effective elastance of the respiratory system. Inspiratory prolongation is a measure for the reflex influence on inspiratory duration, and effective elastance reflects load compensating ability. Inspiratory prolongation was 7.3% +/- 33.5% in infants with apnea and 30.6% +/- 22.7% in the control group (P less than .025). Effective elastance was 1.1 +/- 0.5 cm H2O/mL in the apneic group and 1.5 +/- 0.5 cm H2O/mL in the infants without apnea (P less than .025). The results indicate that during exposure to respiratory loads, the infants with apnea maintained inspiratory effort poorly and had a decreased ability for load compensation. Their respiratory reflexes were significantly more immature than the reflex activity of the infants without apnea. This functional immaturity of respiratory reflexes may be a contributing factor in the etiology of apnea of prematurity.
Authors:
T Gerhardt; E Bancalari
Related Documents :
2084999 - Laser supraarytenoidectomy for laryngomalacia with apnea.
487889 - Neonatal respiratory instability and infant development.
6650989 - Effects of a face mask and pneumotachograph on breathing in sleeping infants.
7263389 - Maturational changes of reflexes influencing inspiratory timing in newborns.
1271169 - Urinary biogenic amines in idiopathic apnea of prematurity.
2251079 - Sudden infant death syndrome and possible relation to vestibular function.
18310179 - Motivations of mothers to enroll their newborn infants in general clinical research on ...
7141139 - Comparison of auditory brain stem response latency norms for premature infants.
23112249 - Two-year follow-up study on neurodevelopmental outcomes after term intrapartum asphyxia...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  74     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-07-27     Completed Date:  1984-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Air Pressure
Airway Obstruction / complications
Apnea / physiopathology*
Esophagus / physiopathology
Humans
Infant, Newborn
Infant, Premature, Diseases / physiopathology*
Reflex / physiology*
Respiration*
Tidal Volume
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Job satisfaction and stress among neonatologists.
Next Document:  Septic dermatitis of the neonatal scalp and maternal endomyometritis with intrapartum internal fetal...