Document Detail

Apnea of prematurity: II. Respiratory reflexes.
MedLine Citation:
PMID:  6739219     Owner:  NLM     Status:  MEDLINE    
Airway obstruction is a cause of apnea in preterm infants. The activity of protective respiratory reflexes was determined in 18 preterm infants with apnea (mean of 32 episodes of more than 20 seconds duration per day) and in 18 neonates without apnea used as control subjects. This was done in order to elucidate the role of respiratory reflexes in apnea of prematurity. The infants were matched for birth weight (1,068 g v 1,065 g), gestational age (30.2 weeks v 30.2 weeks), and postnatal age (8.6 days v 8.3 days). The airway occlusion technique was used to determine the inspiratory prolongation of the occluded breath and the effective elastance of the respiratory system. Inspiratory prolongation is a measure for the reflex influence on inspiratory duration, and effective elastance reflects load compensating ability. Inspiratory prolongation was 7.3% +/- 33.5% in infants with apnea and 30.6% +/- 22.7% in the control group (P less than .025). Effective elastance was 1.1 +/- 0.5 cm H2O/mL in the apneic group and 1.5 +/- 0.5 cm H2O/mL in the infants without apnea (P less than .025). The results indicate that during exposure to respiratory loads, the infants with apnea maintained inspiratory effort poorly and had a decreased ability for load compensation. Their respiratory reflexes were significantly more immature than the reflex activity of the infants without apnea. This functional immaturity of respiratory reflexes may be a contributing factor in the etiology of apnea of prematurity.
T Gerhardt; E Bancalari
Related Documents :
1928959 - Motor activity and apnea in preterm infants. is there a causal relationship?
2656239 - Analysis of components of fetal breathing cycles.
6637479 - A case of near-miss sids developing an abnormal respiratory reaction to hypoxia.
2314939 - Periodic breathing and apnea in preterm infants.
2251079 - Sudden infant death syndrome and possible relation to vestibular function.
3737299 - Cerebrospinal fluid endorphins and the infant apnea syndrome.
7028339 - Red blood cell volume in preterm neonates.
8764909 - High postmortem concentrations of hypoxanthine and urate in the vitreous humor of infan...
6830269 - Umbilical venous blood ph: a useful aid in the diagnosis of asphyxia at birth.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  74     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-07-27     Completed Date:  1984-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Air Pressure
Airway Obstruction / complications
Apnea / physiopathology*
Esophagus / physiopathology
Infant, Newborn
Infant, Premature, Diseases / physiopathology*
Reflex / physiology*
Tidal Volume
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Job satisfaction and stress among neonatologists.
Next Document:  Septic dermatitis of the neonatal scalp and maternal endomyometritis with intrapartum internal fetal...