Document Detail

Apnea is not prolonged by acid gastroesophageal reflux in preterm infants.
MedLine Citation:
PMID:  16263989     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the temporal relationship between apnea and gastroesophageal reflux (GER) and to assess the effect of GER on apnea duration. METHODS: A total of 119 preterm infants underwent 12-hour cardiorespiratory monitoring studies using respiratory inductance plethysmography, heart rate, oxygen saturation (SaO2), and esophageal pH. The studies were scored for GER (pH <4 for > or =5 seconds) and apnea > or =15 seconds or > or =10 seconds that occurred within 30 seconds of GER. Apnea > or =10 seconds was used to assess whether GER would prolong apnea duration. RESULTS: There were 6255 episodes of GER. Only 1% of GER episodes were associated with apnea > or =15 seconds, and there was no difference in apnea rate before, during, or after GER. There was also no difference in rate of apnea > or =10 seconds before versus during GER; however, there was a decrease in apnea rate immediately after GER. The presence of GER during apnea did not prolong apnea duration, and GER had no effect on the lowest SaO2 or heart rate during apnea. CONCLUSION: There is no evidence of a temporal relationship between acid-based GER and apnea in preterm infants. In addition, GER does not prolong apnea duration and does not exacerbate the resultant decrease in heart rate and SaO2.
Juliann M Di Fiore; Marina Arko; Meghan Whitehouse; Amy Kimball; Richard J Martin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  116     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-02     Completed Date:  2005-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1059-63     Citation Subset:  AIM; IM    
Department of Pediatrics, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA.
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MeSH Terms
Apnea / etiology*,  physiopathology
Esophageal pH Monitoring
Gastroesophageal Reflux / complications*,  diagnosis,  physiopathology
Heart Rate
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases* / physiopathology
Monitoring, Physiologic
Oxygen / blood
Reg. No./Substance:
Comment In:
Pediatrics. 2005 Nov;116(5):1217-8   [PMID:  16264010 ]

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