Document Detail


Apnea and bradycardia due to anaphylaxis to tobacco glycoprotein in the infant rabbit.
MedLine Citation:
PMID:  14757378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prenatal and postnatal exposure to cigarette smoke is associated with an increased incidence of the sudden infant death syndrome, although the cause(s) for this is unknown. Tobacco glycoprotein (TGP), a group of proteins purified from cured tobacco leaves and present in cigarette smoke, have been shown to cause anaphylaxis in excised hearts and lungs of adult rabbits that were neonatally sensitized to TGP and later rechallenged. We sought to determine whether anaphylaxis occurred in live infant rabbits who were neonatally sensitized to TGP. At the age of 1 day, 12 animals were sensitized to TGP (0.1mg in 0.25 cc alum) via intraperitoneal injection (i.p.i.) followed by a booster ipi at the age of 30 days (TGP-S). Seven animals received i.p.i. of antigen-free alum only (controls). All animals underwent an intravenous TGP challenge at age 42+/-2 days. Heart rate (HR) and respiratory rate (RR) were recorded for 2 min prior to and 5 min after the challenge. Baseline HR (approximately 260) and RR (approximately 120) were similar in all animals. Seven TGP-S animals developed apnea (1.9-4.7s) within 60s of the challenge while none of the controls did. The TGP-S also became bradycardic (the lowest HR over 50 consecutive beats), with the HR decreasing from 260 to 220 vs the controls, whose HR remained constant (approximately 250). We conclude that some rabbits neonatally sensitized to TGP develop apnea and bradycardia upon further intravenous TGP challenge. These studies suggest that cigarette smoke exposure may be associated with a higher rate of SIDS via an anaphylactic mechanism.
Authors:
William M Gershan; Carl G Becker; Hubert V Forster; Nathaniel S Besch; Timothy F Lowry
Related Documents :
1586058 - The effect of maternal smoking during pregnancy on early infant lung function.
1667938 - Igg subclasses in foetal cord and maternal serum: associations with infections in infan...
843468 - Smoking in pregnancy--effects on birth weight and on cyanide and thiocyanate levels in ...
18717188 - Regression analysis of maternal smoking effect on birth weight.
23034368 - Exploration and innovation in addressing maternal, infant and neonatal mortality.
6259308 - Defective oxidative metabolic responses of neutrophils from stressed neonates.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental research     Volume:  94     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-03     Completed Date:  2004-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  152-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Medical College of Wisconsin, Children's Hospital of Wisconsin, 9000 West Wisconsin Avenue, MS #777A, Milwaukee, WI 53226, USA. wgershan@mcw.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anaphylaxis / etiology*,  veterinary*
Animals
Animals, Newborn
Antigens
Apnea / etiology*,  veterinary
Bradycardia / etiology*,  veterinary
Complement Activation
Glycoproteins / adverse effects,  immunology*
Humans
Immunization
Infant, Newborn
Injections, Intraperitoneal
Phenols / adverse effects,  immunology*
Plant Proteins
Rabbits
Sudden Infant Death / etiology*
Tobacco Smoke Pollution / adverse effects*
Chemical
Reg. No./Substance:
0/Antigens; 0/Glycoproteins; 0/Phenols; 0/Plant Proteins; 0/TGP protein, Nicotiana tabacum; 0/Tobacco Smoke Pollution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Weak electromagnetic fields (50 Hz) elicit a stress response in human cells.
Next Document:  Fish consumption and other environmental exposures and their associations with serum PCB concentrati...