| Aplastic anemia and paroxysmal nocturnal hemoglobinuria: a follow-up study of the glycosylphosphatidylinositol-anchored proteins defect. | |
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MedLine Citation:
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PMID: 11920198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Flow cytometry analysis of peripheral blood cells is a simple and reliable method for establishing the diagnosis of paroxysmal nocturnal hemoglobinuria. The behavior of the clone may vary; increasing or diminishing over time but prospective study of such variations have not been reported so far. MATERIALS AND METHODS: We report herein the results of a prospective follow-up study of 25 patients. Our aims were twofold: first, to evaluate the behavior of the clone (using flow cytometry) over the time; and second, to evaluate if such variations could predict the occurrence of complications or could be used as a tool for monitoring the residual disease after bone marrow transplantation. RESULTS: It was found that flow cytometry can be used to specifically follow the residual disease post allogeneic marrow transplantation in four patients, and that even without transplantation the defective clone can significantly decrease or even disappear (three patients). CONCLUSION: We found that most of the patients did have significant change in the amount of affected cells during more than three years, and that an increased size of the clone poorly predicted the occurrence of complications. |
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Authors:
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M E Noguera; V Leymarie; E Bittencourt; E Gluckman; F Sigaux; G Socié |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The hematology journal : the official journal of the European Haematology Association / EHA Volume: 1 ISSN: 1466-4860 ISO Abbreviation: Hematol. J. Publication Date: 2000 |
Date Detail:
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Created Date: 2002-03-28 Completed Date: 2002-06-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100965523 Medline TA: Hematol J Country: England |
Other Details:
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Languages: eng Pagination: 250-3 Citation Subset: IM |
Affiliation:
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Laboratoire Central d'Hématologie, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Aplastic / blood, complications, drug therapy, pathology*, therapy Antilymphocyte Serum / therapeutic use Blood Cell Count Bone Marrow Transplantation Clone Cells / pathology Combined Modality Therapy Cyclosporine / therapeutic use Female Flow Cytometry Follow-Up Studies Glycosylphosphatidylinositols / deficiency* Hemoglobinuria, Paroxysmal / blood, complications, drug therapy, pathology*, therapy Humans Immunosuppressive Agents / therapeutic use Immunotherapy Male Membrane Proteins / deficiency, genetics Middle Aged Pregnancy Pregnancy Complications, Hematologic / blood, pathology Prospective Studies T-Lymphocytes Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Antilymphocyte Serum; 0/Glycosylphosphatidylinositols; 0/Immunosuppressive Agents; 0/Membrane Proteins; 0/phosphatidylinositol glycan-class A protein; 59865-13-3/Cyclosporine |
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