Document Detail


Aplastic anemia is associated with HLA-DRB1*1501 in northern Han Chinese.
MedLine Citation:
PMID:  10905054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been reported that aplastic anemia (AA) is more common in HLA-DR2-positive individuals than in the general population. We investigated the frequency of some HLA loci of 102 Northern Han Chinese patients with AA and 105 healthy control subjects. Polymerase chain reaction and sequence specific oligonucleotide probe hybridization were used to determine HLA-DR- and HLA-DR2-related DRB1 alleles. The frequency of DR2 is increased in AA patients; the relative risk (RR) was 2.86, and the difference was significant (chi 2 = 11.1, P = .004). The RR of HLA-DRB1*1501 was 3.07, and the difference was significant (chi 2 = 9.42, P = .008). The above results suggest that HLA-DR2 is significantly associated with AA in Northern Han Chinese. HLA-DRB1*1501 is the main subtype of HLA-DR2, and may be the susceptibility gene of AA.
Authors:
W Shao; D Tian; C Liu; X Sun; X Zhang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of hematology     Volume:  71     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-11     Completed Date:  2000-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  350-2     Citation Subset:  IM    
Affiliation:
Department of Hematology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing, China. wenshuo@263.net
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MeSH Terms
Descriptor/Qualifier:
Alleles
Anemia, Aplastic / genetics,  immunology*
Asian Continental Ancestry Group / genetics
Gene Frequency
HLA-DR Antigens / blood,  genetics*
Humans
Oligonucleotide Probes
Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/HLA-DR Antigens; 0/Oligonucleotide Probes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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