Document Detail

Aplastic anemia after prolonged ingestion of indomethacin.
MedLine Citation:
PMID:  6801896     Owner:  NLM     Status:  MEDLINE    
Two rare cases of aplastic anemia after prolonged ingestion of indomethacin are described. One patient recovered spontaneously within several weeks following discontinuation of the drug while the second one died. The aplastic anemia may be related to the inhibitory effect of indomethacin on prostaglandins and cyclic nucleotides which have a regulatory role in erythropoiesis and myelopoiesis.
A Kornberg; E A Rachmilewitz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta haematologica     Volume:  67     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1982  
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  136-8     Citation Subset:  IM    
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MeSH Terms
Anemia, Aplastic / chemically induced*
Bone Diseases / drug therapy
Erythropoiesis / drug effects
Indomethacin / adverse effects*,  therapeutic use
Joint Diseases / drug therapy
Knee Joint
Middle Aged
Nucleotides, Cyclic / metabolism
Prostaglandins / metabolism
Time Factors
Reg. No./Substance:
0/Nucleotides, Cyclic; 0/Prostaglandins; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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