Document Detail

Aplasia cutis congenita of the scalp in an infant exposed to valproic acid in utero.
MedLine Citation:
PMID:  7949818     Owner:  NLM     Status:  MEDLINE    
We report a newborn with isolated aplasia cutis congenita of the scalp whose mother was treated with valproic acid during pregnancy. Aplasia cutis congenita has been described in infants exposed in utero to antithyroid drugs, but has not been related to other tetratogenic agents. Fetal exposure to valproic acid is known to increase the risks of spina bifida and other midline defects. Interestingly, aplasia cutis congenita of the scalp is regarded as a cutaneous marker for neural dysraphism. However, this defect of the scalp and valproic acid intake during pregnancy may be a random association and similar observations are needed to suggest causality.
A Hubert; D Bonneau; D Couet; M Berthier; D Oriot; M Larrègue
Related Documents :
6209698 - Predictive value of amniotic acetylcholinesterase analysis in the diagnosis of fetal ab...
95198 - Heterogeneity, immunological comparison and concentration profiles of alpha-fetoprotein...
3849408 - Some aspects of late abortion for congenital abnormality.
2447578 - Prenatal diagnosis of neural tube defects by measurement of serum alpha-fetoprotein in ...
952628 - A current appraisal of side effects of oral contraceptives.
17465388 - Fetal spina bifida in a mouse model: loss of neural function in utero.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  83     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  789-90     Citation Subset:  IM    
Unité de Génétique Médicale, Centre Hospitalier Universitaire de Poitiers, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abnormalities, Drug-Induced / epidemiology,  etiology*
Epilepsy / drug therapy
Infant, Newborn
Pregnancy Complications / drug therapy
Prenatal Exposure Delayed Effects*
Scalp / abnormalities*
Valproic Acid / adverse effects*
Reg. No./Substance:
99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Congenital varicella syndrome: studies of the virus-specific humoral and cell-mediated immune respon...
Next Document:  Agenesis of pancreas.