Document Detail


Aplasia cutis congenita of the scalp in an infant exposed to valproic acid in utero.
MedLine Citation:
PMID:  7949818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a newborn with isolated aplasia cutis congenita of the scalp whose mother was treated with valproic acid during pregnancy. Aplasia cutis congenita has been described in infants exposed in utero to antithyroid drugs, but has not been related to other tetratogenic agents. Fetal exposure to valproic acid is known to increase the risks of spina bifida and other midline defects. Interestingly, aplasia cutis congenita of the scalp is regarded as a cutaneous marker for neural dysraphism. However, this defect of the scalp and valproic acid intake during pregnancy may be a random association and similar observations are needed to suggest causality.
Authors:
A Hubert; D Bonneau; D Couet; M Berthier; D Oriot; M Larrègue
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  83     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  789-90     Citation Subset:  IM    
Affiliation:
Unité de Génétique Médicale, Centre Hospitalier Universitaire de Poitiers, France.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / epidemiology,  etiology*
Adult
Causality
Epilepsy / drug therapy
Female
Humans
Infant, Newborn
Male
Pregnancy
Pregnancy Complications / drug therapy
Prenatal Exposure Delayed Effects*
Scalp / abnormalities*
Valproic Acid / adverse effects*
Chemical
Reg. No./Substance:
99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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