| Aplasia cutis congenita of the scalp in an infant exposed to valproic acid in utero. | |
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MedLine Citation:
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PMID: 7949818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a newborn with isolated aplasia cutis congenita of the scalp whose mother was treated with valproic acid during pregnancy. Aplasia cutis congenita has been described in infants exposed in utero to antithyroid drugs, but has not been related to other tetratogenic agents. Fetal exposure to valproic acid is known to increase the risks of spina bifida and other midline defects. Interestingly, aplasia cutis congenita of the scalp is regarded as a cutaneous marker for neural dysraphism. However, this defect of the scalp and valproic acid intake during pregnancy may be a random association and similar observations are needed to suggest causality. |
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Authors:
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A Hubert; D Bonneau; D Couet; M Berthier; D Oriot; M Larrègue |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 83 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-12-20 Completed Date: 1994-12-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: NORWAY |
Other Details:
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Languages: eng Pagination: 789-90 Citation Subset: IM |
Affiliation:
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Unité de Génétique Médicale, Centre Hospitalier Universitaire de Poitiers, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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epidemiology,
etiology* Adult Causality Epilepsy / drug therapy Female Humans Infant, Newborn Male Pregnancy Pregnancy Complications / drug therapy Prenatal Exposure Delayed Effects* Scalp / abnormalities* Valproic Acid / adverse effects* |
| Chemical | |
Reg. No./Substance:
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99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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