| Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma. | |
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MedLine Citation:
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PMID: 20095800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many flavonoids were demonstrated to possess the antiallergic effect. Here we detected whether apigenin, a flavonoid, can attenuate allergen-induced airway inflammation and what is the possible mechanism in a murine model of asthma. Apigenin decreased the degree of the inflammatory cell infiltration, airway hyperresponsiveness, and total immunoglobulin E levels compared with the ovalbumin group. In addition, apigenin triggered the switching of the immune response to allergens toward a T-helper type 1 (Th1) profile. Our data clearly demonstrated that apigenin exhibits an anti-inflammatory activity in a murine asthma model, and can switch the immune response to allergens toward the Th1 profile. |
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Authors:
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Ruo-Ran Li; Ling-Ling Pang; Qiang Du; Ying Shi; Wen-Jing Dai; Kai-Sheng Yin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunopharmacology and immunotoxicology Volume: 32 ISSN: 1532-2513 ISO Abbreviation: Immunopharmacol Immunotoxicol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-09 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800150 Medline TA: Immunopharmacol Immunotoxicol Country: England |
Other Details:
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Languages: eng Pagination: 364-70 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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immunology* Animals Anti-Asthmatic Agents / therapeutic use* Anti-Inflammatory Agents / therapeutic use* Apigenin / therapeutic use* Asthma / drug therapy*, immunology Bronchial Hyperreactivity / drug therapy, immunology Bronchial Provocation Tests Female Immunoglobulin E / analysis, immunology Mice Mice, Inbred BALB C Th1 Cells / drug effects, immunology |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Anti-Asthmatic Agents; 0/Anti-Inflammatory Agents; 37341-29-0/Immunoglobulin E; 520-36-5/Apigenin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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