| Apigenin induces apoptosis in human lung cancer H460 cells through caspase- and mitochondria-dependent pathways. | |
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MedLine Citation:
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PMID: 20937639 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Apigenin (4,5,7-trihydroxyflavone), a promising chemopreventive agent presented in fruits and vegetables, has been shown to induce cell cycle arrest and apoptosis in many types of human cancer cell lines. However, there is no available information to address the effects of apigenin on human lung cancer H460 cells. In the present studies, H460 cells were treated with apigenin for different time and then were analyzed for the morphological changes, induction of apoptosis, protein levels associated with apoptosis and results in dose-dependent induction of morphological changes, decrease in the percentage of viability, induced DNA damage and apoptosis; down-modulation of the protein expression of Bid, Bcl-2, procaspase-8; up-regulation of protein levels of Bax, caspase-3, AIF, cytochrome c, GRP78 and GADD153; decreased the levels of mitochondrial membrane potential and increased the productions of reactive oxygen species (ROS) and Ca(2+) in H460 cells. Taken together, this is the first systematic in vitro study showing the involvement of apoptosis regulatory proteins as potential molecular targets of apigenin in human lung cancer H460 cells. |
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Authors:
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Hsu-Feng Lu; Yu-Jie Chie; Ming-Sung Yang; Kung-Wen Lu; Jene-John Fu; Jai-Sing Yang; Hung-Yi Chen; Te-Chun Hsia; Chia-Yu Ma; Siu-Wan Ip; Jing-Gung Chung |
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Publication Detail:
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Type: Journal Article Date: 2010-10-11 |
Journal Detail:
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Title: Human & experimental toxicology Volume: 30 ISSN: 1477-0903 ISO Abbreviation: Hum Exp Toxicol Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9004560 Medline TA: Hum Exp Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1053-61 Citation Subset: IM |
Affiliation:
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Department of Clinical Pathology, Cheng Hsin General Hospital, Taipei, Taiwan, Department of Restaurant, Hotel and Institutional Management, Fu-Jen Catholic University, Taipei, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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