Document Detail


Apicomplexan parasites and subversion of the host cell microRNA pathway.
MedLine Citation:
PMID:  21840260     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
RNA silencing plays a major role in innate antiviral and antibacterial defenses in plants, insects, and animals through the action of microRNAs (miRNAs). miRNAs can act in favor of the microorganism, either when it is pathogen-encoded or when the microorganism subverts host miRNAs to its benefit. Recent data point to the possibility that apicomplexan parasites have developed tactics to interfere with host miRNA populations in a parasite-specific manner, thereby identifying the RNA-silencing pathway as a new means to reshape their cellular environment. This review highlights the current understanding and new insights concerning the mechanisms that could be involved and the potential roles of the host microRNome (miRNome) in apicomplexan infection.
Authors:
Mohamed-Ali Hakimi; Dominique Cannella
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-11
Journal Detail:
Title:  Trends in parasitology     Volume:  -     ISSN:  1471-5007     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966034     Medline TA:  Trends Parasitol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Unité Mixte de Recherche 5163, Laboratoire Adaptation et Pathogénie des Micro-organismes, Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier Grenoble 1, BP 170, F-38042 Grenoble CEDEX 9, France.
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